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Diss Factsheets
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EC number: 222-394-5 | CAS number: 3458-72-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report For SIAM 19
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- OECD SIDS initial assessment report
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Description of methods used in BASF acute toxicity and skin/eye irritation studies before pertinent OECD/EU test guidelines were in place (BASF AG, 2002)
- Version / remarks:
- 2002
- Deviations:
- no
- Principles of method if other than guideline:
- - Principle of test:
Description of methods used in BASF acute toxicity and skin/eye irritation studies before pertinent OECD/EU test guidelines were in place; similar to standard acute method
- Short description of test conditions: The test substance was given by single gavage to groups of rats at various dose levels as a 30% aqueous solution. 10 male and 10 female rats were used per dose level. The LD50 was calculated according to the method described by Litchfield-Wilcoxon.
- Parameters analysed / observed: not reported - GLP compliance:
- not specified
- Test type:
- other: similar to standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ammonium sulphate
- EC Number:
- 231-984-1
- EC Name:
- Ammonium sulphate
- Cas Number:
- 7783-20-2
- Molecular formula:
- H3N.1/2H2O4S
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner Strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test substance was applied as 30% solution
- Doses:
- 2500, 3200, 4000, 5000, 6400 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Statistics:
- The LD50 was calculated according to the method described by Litchfield-Wilcoxon.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 788 - <= 4 769
- Mortality:
- Group 6400 mg/kg bw: 12 died within the first hour, 2 within 24 hours, 4 within 48 hours; in total, 18/20 died within 7 days.
Group 5000 mg/kg bw: 8 died within the first hour, 1 within 24 hours, 1 within 48 hours; in total 11/20 died within 7 days.
Group: 4000 mg/kg bw: 7 died within 24 hours, and 2 within 48 hours; in total, 9/20 died within 7 days.
Group 3200 mg/kg bw: 1 animal died within the first hour, 1 within 24 hours, 2 within 48 hours; in total, 4/20 died within 7 days.
Group 2500 mg/kg bw: no deaths occurred. - Clinical signs:
- 4000-6400 mg/kg bw: immediately after application staggering, abdominal and lateral position, partly dorsal position, apathy, laboured and irregular breathing. On the next day, secretion out of eyes and mouth, reddened eyes and nose. In the post-exposure observation days the animals were without clinical symptoms.
3200 mg/kg bw: No symptoms on the application day. The next day, reddened eyes and nose, and irregular breathing were noted. Later without clinical signs.
2500 mg/kg bw: No clinical signs noted. - Gross pathology:
- At necropsy, fluid in the thoracic cavity was observed in a few animals. In three animals, the stomach was filled with liquid, and bloody mouth and forelegs were noted. No pathological findings were noted with regard to the inner organs.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the study which was reported in the OECD SIDS report (2004) the LD50 value of 4250 mg/kg bw was determined using the Litchfield-Wilcoxon Method, thus the substance does not need to be classified according to Regulation (EC) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling of Chemicals (GHS).
- Executive summary:
According to the study which was reported in the OECD SIDS report (2004) the LD50 value of 4250 mg/kg bw was determined using the Litchfield-Wilcoxon Method, thus the substance does not need to be classified according to Regulation (EC) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling of Chemicals (GHS).
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