Registration Dossier
Registration Dossier
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EC number: 846-827-8 | CAS number: 1521274-68-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- screening study on acute oral toxicity study in rats; two groups of 3 animals each were administered 300 mg/kg bw and monitored for 14 days
- GLP compliance:
- no
- Test type:
- other: only one dose tested
- Limit test:
- no
Test material
- Reference substance name:
- N-ethylpyridazin-4-amine
- EC Number:
- 846-827-8
- Cas Number:
- 1521274-68-9
- Molecular formula:
- C6H9N3
- IUPAC Name:
- N-ethylpyridazin-4-amine
- Details on test material:
- - State of aggregation: solid/brown
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- 3.0 g/100 mL in 1 % CMC-solution
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 300 mg/kg bw
- No. of animals per sex per dose:
- 2 x 3 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at 0-5 hours, 1 d, 2 d, 7 d, 14 d
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 300 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- Piloerection, unsteady gait, slight, semiclosed eyelids
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- BASF non-GLP screening-study on acute oral toxicity in rats:
only 300 mg/kg bw dose tested with no mortality; but based on clinical signs mortality < 2000 mg/kg bw cannot be excluded.
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