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EC number: 220-638-5 | CAS number: 2842-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
Test material
- Reference substance name:
- 2-(N-methyl-p-toluidino)ethanol
- EC Number:
- 220-638-5
- EC Name:
- 2-(N-methyl-p-toluidino)ethanol
- Cas Number:
- 2842-44-6
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 2-[methyl(4-methylphenyl)amino]ethan-1-ol
- Test material form:
- liquid: viscous
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.062 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.115 Pa
Any other information on results incl. tables
1 Results
1.1 Test Item
The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):
Table 10.1-a Experimentally Determined Vapour Pressures
T |
T |
p |
Stand. Dev. p |
RSD p |
°C |
K |
Pa |
Pa |
% |
30.0 |
303.2 |
2.09E-01 |
3.66E-03 |
1.8% |
45.0 |
318.2 |
1.12E+00 |
4.36E-02 |
3.9% |
60.0 |
333.2 |
5.04E+00 |
3.17E-01 |
6.3% |
In this table, E-0X represents multiplication with 10-X.
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
For the test item N-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT), the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Table 10.1-b Results Test Item
Vapour pressure at 20°C: |
6.25* 10-02Pa |
Vapour pressure at 25°C: |
1.15* 10-01Pa |
The linear regression of log p vs. 1/T gave a correlation coefficient r of - 1.0000, showing good repeatability and precision. Therefore, the determination is considered as valid.
1.2 Positive Control
For Diethylphthalate the following vapour pressure was determined and compared with recommended value:
Table 10.2-a Results Positive Control
Vapour pressure (positive control) at 30°C: |
1.29*10-1Pa |
Criterion for the vapour pressure of the positive control at 30°C |
0.44*10-1- 2.44*10-1Pa |
The vapour pressure met the validity criteria. Therefore the study can be considered as valid.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the test item N-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT) was determined at three different temperatures (30, 45 and 60°C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss).
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard devia-tions of less than 7 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid. - Executive summary:
The vapour pressure ofN-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT)was determinedaccording to OECD 104 resp.EU A.4 using the effusion method (weight loss).
Vapour pressure was examined atthree different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).
Table3‑a Vapour Pressures (Effusion Method)
Experiment
T
Mean p
Stand. Dev. p
RSD p
No.
K
Pa
Pa
%
1
303.2
2.09E-01
3.66E-03
1.8%
2
318.2
1.12E+00
4.36E-02
3.9%
3
333.2
5.04E+00
3.17E-01
6.3%
In this table, E-0X represents multiplication with 10-x.
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
The graph log (p) vs. 1/T shows a straight line with a correlation coefficient of - 1.0000.
For the test itemN-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT), the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 6.25* 10-02Pa
Vapour pressure at 25 °C: 1.15* 10-01Pa
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