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Diss Factsheets
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EC number: 950-463-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- Minor deviations were noted but these did not have an impact on the overall study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- A method has been proposed by Thomas and Burosse to improve the current OECD 105 Water Solubility test design for poorly water soluble liquids by incorporating a portion of another OECD guideline (OECD 123) This method is very similar to a previous method used by Varaprath et al to determine the solubility of several poorly soluble permethylsiloxanes. The test article was anticipated to be so poorly soluble, that the current methods listed in OECD 105 are inappropriate.
- Deviations:
- yes
- Remarks:
- Minor deviations were noted but these did not have an impact on the overall study
- Principles of method if other than guideline:
- A method has been proposed by Thomas and Burosse to improve the current OECD 105 Water Solubility test design for poorly water soluble liquids by incorporating a portion of another OECD guideline (OECD 123) This method is very similar to a previous method used by Varaprath et al to determine the solubility of several poorly soluble permethylsiloxanes. The test article was anticipated to be so poorly soluble, that the current methods listed in OECD 105 are inappropriate.
- GLP compliance:
- yes
- Type of method:
- other: This method is very similar to a previous method used by Varaprath et al to determine the solubility of several poorly soluble permethylsiloxanes
Test material
- Reference substance name:
- Reaction mass of Methacryloxypropyl (tris(trialkylsiloxy)silylethyl dimethylsiloxy) silane and oligomers
- EC Number:
- 950-463-6
- Molecular formula:
- C(33-81)H(86-214)O(11-25)Si(11-28)
- IUPAC Name:
- Reaction mass of Methacryloxypropyl (tris(trialkylsiloxy)silylethyl dimethylsiloxy) silane and oligomers
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- < 7.17 other: ng/g
- Conc. based on:
- test mat.
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- The solubility of the test article in water is less than the method detection limit of 7.17 ng/g.
- Details on results:
- The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.
Applicant's summary and conclusion
- Conclusions:
- The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.
- Executive summary:
The objective of this study was to experimentally determine the aqueous solubility of HESlO108. The study was conducted in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123)3 to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit in matrix of 7.17 ng/g.
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