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EC number: 817-766-4 | CAS number: 91891-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- This was a screening study so 3 males per dose were utilized.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- EC Number:
- 817-766-4
- Cas Number:
- 91891-42-8
- Molecular formula:
- C6F12O
- IUPAC Name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3M Company
- Expiration date of the lot/batch: No data
- Purity test date: 19 June, 2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: None, test material administered as recieved
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan/Envigo
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 173-193 g
- Fasting period before study: None
- Housing: All rats were group housed in solid bottom cages prior to the study and throughout the 14-day recovery period.
- Diet (e.g. ad libitum): Harlan Teklad Rat/Mouse 2018 Diet, ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6-22.2
- Humidity (%): 30-70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 18 July, 2017 To: 01 August, 2017
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 51 L static test chamber (TSE Systems, GmbH, Bad Hombur, Germany)
- Exposure chamber volume: 51 L
- Method of holding animals in test chamber: None, whole body exposure
- Source and rate of air: 2.9 LPM
- Method of conditioning air: No data
- System of generating particulates/aerosols: None, vapor
- Method of particle size determination: None, vapor
- Temperature, humidity, pressure in air chamber: Mean of 23.2 C, 61.5% relative humidity, and oxygen concentrations ranging from 18.6-20.3%
TEST ATMOSPHERE
- Brief description of analytical method used: The test material and oxygen concentrations during the exposures were monitored in real time by gas chromatography (GC). An Agilent Model 490 micro GC was utilized for this study via thermal conductivity detector under isothermal conditions and the test material showed adequate sensitivity.
- Samples taken from breathing zone: No data
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: Computational toxicology was utilized to estimate a starting dose for the class method. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 0 ppm, 1,547 ppm (20.3 mg/L), 10,200 ppm (131.8 mg/L)
- No. of animals per sex per dose:
- 3 males per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Each animal was observed throughout the study to clinical signs of toxicity. All notable findings were recorded. Body weights were recorded for all animals prior to exposure and daily thereafter through the end of the observation period.
- Necropsy of survivors performed: yes, gross necropsy
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 20.3 - < 131.8 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- One rat had continuous seizures every 30 seconds for one hour and was subsequently euthanized 2 hours post-exposure; necropsy revealed foam and fluid-filled trachea and red fluid dripping from nares. The remaining 2 rats from the 10,200 ppm exposure group were found dead the following day, necropsy showed lungs were dark cherry red.
- Clinical signs:
- other: Rats exposed to 1,570 ppm (20.3 mg/L) of the test article demonstrated no adverse clinical signs of toxicity and all survived the 4 hour exposure and 14 day recovery period. During the 10,200 ppm (131.8 mg/L) exposure, adverse clinical signs included spo
- Body weight:
- No abnormal changes in body weight were noted in the animals exposed to 1,570 ppm (20.3 mg/L).
- Gross pathology:
- One rat had continuous seizures every 30 seconds for one hour and was subsequently euthanized 2 hours post-exposure; necropsy revealed foam and fluid-filled trachea and red fluid dripping from nares. The remaining 2 rats from the 10,200 ppm exposure group were found dead the following day, necropsy showed lungs were dark cherry red.
No findings were noted in the 1,570 ppm (20.2 mg/L) group upon necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, the 4-hour LC50 of the test article is greater than 20.3 mg/L (1,570 ppm) and less than 131 mg/L (10,200 ppm).
- Executive summary:
Male rats (3/sex/group) received whole body exposure to control (ambient air), 1,570 ppm (20.3mg/L), or 10,200 ppm (132 mg/L) test article (vapor) for 4 hours. Rats exposed to 1,570 ppm test article demonstrated no adverse clinical signs of toxicity and all survived the 4 hour exposure and 14 day recovery period. During the 10,200 ppm test article exposure adverse clinical signs included sporadic movement, urinary incontinence, sneezing, lethargy, and prostrate posture with diminished response to noise stimuli. Following the 4 hour exposure rats exposed to 10,200 ppm test article demonstrated twitching/headshaking, lethargy, no grip strength, cool to the touch appendages, prostrate posture, and unkempt appearance. One rat had continuous seizures every 30 seconds for one hour and was subsequently euthanized 2 hours post-exposure; necropsy revealed foam and fluid-filled trachea and red fluid dripping from nares. The remaining 2 rats from the 10,200 ppm exposure group were found dead the following day, necropsy showed lungs were dark cherry red. Control animals demonstrated no adverse signs of clinical toxicity during the course of the study. Based on the results of the study, the 4-hour LC50 of the test article is greater than 20.3 mg/L (1,570 ppm) and less than 131 mg/L (10,200 ppm).
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