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EC number: 245-327-1 | CAS number: 22919-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1940 - 1951
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data from Cosmetic Ingredient Review published report.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of triethanolamine, diethanolamine and monoethanolamine.
- Author:
- Elder, RE.
- Year:
- 1 983
- Bibliographic source:
- J Am Coll Toxicol. 1983; 2(7):183-235.
- Reference Type:
- publication
- Title:
- Acute and chronic toxicity of triethanolamine.
- Author:
- Kindsvatter, V.H.
- Year:
- 1 940
- Bibliographic source:
- J. Indust. Hyg. Toxicol. 22, 206-212.
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV.
- Author:
- Smyth, H.F., Jr., Carpenter, C.P., and Weil, C.S.
- Year:
- 1 951
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 4, 119-122.
- Reference Type:
- publication
- Title:
- Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics.
- Author:
- Flume et al
- Year:
- 2 013
- Bibliographic source:
- Int J Toxicol. 2013 May-Jun;32(3 Suppl):59S-83S
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Collection of historial acute oral toxicity test results published in the Chemical Ingredient Review - Final Report on the Safety Assessment of TEA, DEA and MEA.
- GLP compliance:
- not specified
Test material
- Specific details on test material used for the study:
- Publication states that Triethanolamine of commercial or high purity grade was used in these studies.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals were adminstered the material by gavage, and then were observed for 14 days.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The animals were adminstered the material by gavage, the LD50 values for 100% Commerical Grade TEA recorded in table 4 of the Safety Assessment are estimated from single feedings.
- Doses:
- Various dose levels are recorded in the Acute Oral Toxicity table (Table 4) of the CIR Safety Report. Dose levels reported for 100% Commercial grade TEA in this report are 1.0 - 26.0 g/Kg.
- No. of animals per sex per dose:
- 10 rats; sex is not specified.
- Details on study design:
- Details on study design for tests conducted with Commericial grade and high purity grade TEA can be found in Kindsvatter, V.H. (1940). Acute and chronic toxicity of triethanolamine. J. Indust. Hyg. Toxicol. 22, 206-212. Details on the study design for Acute oral toxicity study conducted with TEA in water can be found in Smyth, H.F., Jr., Carpenter, C.P., and Weil, C.S. (1951). Range-finding toxicity data: List IV. AMA Arch. Ind. Hyg. Occup. Med. 4, 119-122. In these studies, rats and guinea pigs were administered Triethanolamine by gavage (1-26 g/Kg) and observed for 14 days. The LD50 values were estimated from this single feeding.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Effect level:
- ca. 8 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: TEA, Commercial grade (100%)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 9 000 mg/kg bw
- Remarks on result:
- other: TEA, high purity grade (100%)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 190 mg/kg bw
- Based on:
- other: 25% in water
- Remarks on result:
- other: Mixture of TEA 78.6%, DEA 8.6% and MEA 1.7%
- Clinical signs:
- other: Before death, diarrhoea and prostration was observed in most animals. Gross lesions in the animals that died were confined to the gastrointestinal tract and included gastric dilatation, congestion, and focal hemorrhage in the stomach and dilatation of int
- Gross pathology:
- Gross pathology was confined to the intestinal tract.
- Other findings:
- Kindsvatter (1940) suggested that the acute toxicity of triethanolamine was related to its alkalinity, based on the survival of one guinea pig fed 10 g/kg neutralized with hydrochloric acid; this dose exceeds the oral LD50 (8 g/kg) of triethanolamine when administered as the free base.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this publication, the acute oral LD50 values for Triethanolamine are reported as a range from 4.19 g/kg to 11.26 g/kg, this substance is therefore not classified according to GHS criteria.
- Executive summary:
The acute oral toxicity of Triethanolamine was assessed in the cosmetic ingredient review publication, ‘Final Report on the Safety Assessment of Triethanolamine, Diethanolamine and Monoethanolamine’ (Journal of the American College of Toxicology, 2(7), pg 183–235, (1983)). The results of multiple in vivo acute oral toxicity studies are presented, where acute oral LD50 values range from 4.19 g/kg to 11.26 g/kg. As the results of the acute oral toxicity studies reported did not meet the criteria for classification, it was concluded in this safety assessment that Triethanolamine is practically nontoxic.
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