DL-α-(aminomethyl)-p-hydroxybenzylic alcohol hydrochloride

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 July 2018 to 22 August 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor and D151-1710037
- Expiration date of the lot/batch: 26 October 2019 (retest date)
- Purity test date: 27 October 2017

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

< 0.002 Pa

Key result

Test no.:

#2

Temp.:

20 °C

Vapour pressure:

< 0 mm Hg

Key result

Test no.:

#3

Temp.:

25 °C

Vapour pressure:

< 0.004 Pa

Key result

Test no.:

#4

Temp.:

25 °C

Vapour pressure:

< 0 mm Hg

In the range of 100°C and 130°C a log p versus 1/T curve for the test item could not be determined sincethe coefficient of correlation (r) was < 0.99 (data is archived in the raw data). At higher temperatures reaction and/or decomposition of the test item was observed.

Since no accurate vapour pressure could be calculated from the obtained resultsthe weight losses of the test item were compared with the results of hexachlorobenzene at the same temperatures.The weight loss curve of this reference substance is shown inFigure 5.Since theweight loss of the test item was lower than the weight loss of the reference compound, the vapour pressure of the test item is considered to be below the vapour pressure ofhexachlorobenzene. According to this the vapour pressure of the test item is given in Table 3

the vapour pressure of the test item is given inTable 3.

Table 2          
Results of the Vapour pressure Isothermal TGA Analysis

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
100	0.343118	4.10x10^-5	-4.39	-0.48	0.33
	0.334798	4.00x10^-5	-4.40	-0.49	0.32
110	0.506283	6.04x10^-5	-4.22	-0.26	0.55
	0.507982	6.06x10^-5	-4.22	-0.26	0.55
120	0.536298	6.40x10^-5	-4.19	-0.23	0.59
	0.540463	6.45x10^-5	-4.19	-0.23	0.59
130	0.325474	3.89x10^-5	-4.41	-0.51	0.31
	0.413251	4.93x10^-5	-4.31	-0.38	0.42

Table 3          
Vapour pressure of the Test Item

	20°C		25°C
	[Pa]	[mm Hg]	[Pa]	[mm Hg]
Test item	< 1.5x10^-3	< 1.1x10^-5	< 4.0x10^-3	< 3.0x10^-5

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Octopamine hydrochloride.

The vapour pressure of the test item at 20°C (293K) was <1.5E-3 Pa and < 1.1E-5 mmHg and at 25°C (298K) was < 4.0E-3 and < 3.0E-5 mmHg.

Description of key information

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Octopamine hydrochloride.

The vapour pressure of the test item at 20°C (293K) was <1.5E-3 Pa and < 1.1E-5 mmHg and at 25°C (298K) was < 4.0E-3 and < 3.0E-5 mmHg.

Key value for chemical safety assessment

Vapour pressure:

0.002 Pa

at the temperature of:

20 °C