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EC number: 950-042-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996-03-11 to 1996-03-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was performed acc. to the Guideline and under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methyl-6-(2,4,4-trimethylpentyl)-2H-pyran-2-one
- EC Number:
- 610-555-6
- Cas Number:
- 50650-75-4
- Molecular formula:
- C14 H22 O2
- IUPAC Name:
- 4-methyl-6-(2,4,4-trimethylpentyl)-2H-pyran-2-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrabärbling
The body length of 7 representative fish from each batch was measured.
Batch=3/96/L1; date=12-March-1996; n=7; variation range = 2.5-2.8 cm; mean = 2.6 cm; SD = 0.1;
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.3 mMol Ca(II) and Mg(II)
- Test temperature:
- 21.4 - 22.3 °C (concentration groups)
21.4 - 22.4 °C (controls) - pH:
- 7.8 - 8.1 (concentration groups)
7.8 - 8.1 (controls) - Dissolved oxygen:
- 7.8 - 9.9 mg/L (concentration groups)
7.9 - 9.8 mg/L (controls) - Salinity:
- not indicated
- Nominal and measured concentrations:
- Nominal concentrations: 0 - 1 - 2.5 - 5 - 10 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
Glass-aquaria
- Material, size, headspace, fill volume:
about 10 L per vessel (30 cm x 22cm x 24 cm) placed in a water bath made of Hostalit ZR with a glass pane made of perspex
- Aeration:
none during testing
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
reconstituted water acc. to ISO/DIS 7346/1
preparation in two steel tanks with Hostalen lining
capacity of steel tanks 1000L
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod:
12 hrs with approx. 700 Lux
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 9.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The fish showed changes in appearance and behavior, swimming behavior and respiration rate in the 2.2 - 10 mg/L groups during the entire exposure time. Effects in the 1 mg/L group were reversible within 72 hours of exposure.
Dead fish showed dark colored integument and red opercula.
The individual symptoms are given in the appendix of the study report
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (96h) is 6.1 mg/L based on mean measured concentrations.
- Executive summary:
The test material was tested in zebra fish (Brachydanio rerio) over 96 hours in a static system. The nominal concentrations tested were 1 ; 2.2; 5; 10 mg/L and a negative control (0 mg/L). All tested concentrations were present as clear solutions. All test batches were homogeneous. No particulate matter was observed. The substance concentration was determined in the 5 and 10 mg/L groups. The values determined were in a range of 77 - 98 % of the theoretical value and reveiled a slight decreasing tendency over the study period. The lethality values given in this report are based on mean measured concentrations. In this 96-hour acute toxicity study of the test material the following lethality values were determined based on mean measured concentrations:
24 h 48 h 72 h 96 h LC0 [mg/L] 4.1
4.1
4.1
4.1
LC50 [mg/L] 6.1 6.1 6.1 6.1 LC100 [mg/L] 9.2 9.2 9.2 9.2 Symptoms and lethality were observed at 10 mg/L. The 1 - 5 mg/L groups exhibited symptoms but no lethality.
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