Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 428-650-4 | CAS number: 153719-23-4
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Jan 1998 to 24 Feb 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Experimental Procedure
Mixtures of the test substance with each of the investigated solvents were prepared in glass volumetric flasks. Sufficient substance was added to ensure that saturation was achieved. The contents of each flask were stirred for forty-eight hours at the test temperature of 25.0 °C (± 0.1 °C) in a thermostatically controlled water bath. After this time a representative aliquot from each flask was transferred to a stainless steel centrifuge tube. These tubes were then centrifuged for 40 minutes at 50000 G in a centrifuge, thermostated at 25.0 °C.
Analysis
After centrifugation each centrifuge tube contained a clear supernatant liquid - saturated solution - with a residue of undissolved, excess test substance still present. An aliquot from each clear, saturated solution was subsequently analysed by high performance liquid chromatography to determine the solubility of the test substance in each of the investigated solvents.
The analytical method is sufficiently precise and sensitive, and is specific with respect to known by-products and degradation products. - GLP compliance:
- yes
- Medium:
- acetone
- Solubility:
- 48 g/L
- Temp.:
- 25 °C
- Medium:
- other: dichloromethane
- Solubility:
- 110 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 7 g/L
- Temp.:
- 25 °C
- Medium:
- other: hexane
- Solubility:
- < 1 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 13 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 620 mg/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 680 mg/L
- Temp.:
- 25 °C
- Test substance stable:
- not determined
- Executive summary:
The test was performed in compliance with GLP. The solubility of test substance in different organic solvents is presented below:
Acetone: 48 g/L
Ethyl acetate: 7 g/L
Dichloromethane: 110 g/L
Hexane: < 1 mg/L
Toluene: 680 mg/L
Methanol: 13 g/L
n-octanol: 620 mg/L
Reference
Description of key information
Stulz 1995
Key value for chemical safety assessment
Additional information
The solubility of test substance in different organic solvents is presented below:
Acetone: 48 g/L
Ethyl acetate: 7 g/L
Dichloromethane: 110 g/L
Hexane: < 1 mg/L
Toluene: 680 mg/L
Methanol: 13 g/L
n-octanol: 620 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
