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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
D-8 was tested for acute toxicity to fish in a semistatic 96-hour test according to EU Method C.1. The LC50 value (96 hours) for D-8 in the Red Killifish was determined to be 18.8 mg/L.
Long-term toxicity to fish
In an OECD 215 study, exposure to D-8 did not induce any estrogenic effect, as evidenced by an oviduct formation, up to a concentration of 2 mg/L. The NOEC of D-8 was considered to be greater than 2 mg/L.
Short-term toxicity to aquatic invertebrates
D-8 was tested for toxicity to Daphnia in a 48-h static immobilisation test and the EC50 value was determined to be 12 mg/L.
Long-term toxicity to aquatic invertebrates
D-8 was tested for 21-day juvenile production study in Daphnia magna according to OECD Guideline 202. The 21-day median lethal concentration (LC50) of D-8 to parental Daphnia was calculated to be 2.70 mg/L. The 21-day EC50 values for inhibition of reproduction were 1.90 mg/L based on the total number of juveniles produced at each mean measured concentration, and 2.94 mg/L based on the mean cumulative number of juveniles produced per adult. In conclusion, D-8 significantly affected both the survival of the parental generation and their ability to produce viable juveniles at concentrations above 0.139 mg/L. Therefore, NOEC was determined to be 0.139 mg/L.
Toxicity to aquatic algae and cyanobacteria
The 50 % effect concentrations for average specific growth rate (ErC50) and mean biomass (EbC50) for D-8, respectively, were found to be 5.62 mg/L (95 % confidence limits 4.63 and 16.7 mg/L) and 2.22 mg/L (95 % confidence limits 1.90 and 4.63 mg/L). The no-observed-effect concentration (NOEC) for growth rate and biomass was 0.461 mg/L.
Additional information
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