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EC number: 701-287-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 30 July to 3rd September 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: compliant to GLP and testing guideline; adequate coherence between data, comments and conclusions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- dioxo-1,3-dioxa-2-chroma-4-baracyclobutane; dioxo-2,4-dioxa-3-cupra-1,5-dichromapentane; oxocopper
- EC Number:
- 701-287-1
- Molecular formula:
- CuO, CuCr2O4, BaCrO4
- IUPAC Name:
- dioxo-1,3-dioxa-2-chroma-4-baracyclobutane; dioxo-2,4-dioxa-3-cupra-1,5-dichromapentane; oxocopper
- Details on test material:
- - Name of test material (as cited in study report): Chromite de cuivre
- Substance type: multiconstituents
- Physical state: black powder
- Composition of test material, percentage of components: 34% of copper, 8.5% of baryum, 31% of chrome
- Purity test date: 11 January 2010
- Lot/batch No.: 09/0177
- Expiration date of the lot/batch: 17 August 2014
- Storage condition of test material: in darkness at room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Before and after each renewal, two aliquots of 5 mL were taken in each group containing the test item and in the stock solution.
These aliquots were stored at approximately -16°C (deep frozen) and transferred to ICP-AES unit at the end of test to be analysed for chromium and barium contents determination.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- TEST SOLUTION PREPARATION
As the test item is not soluble in water, the stock solutions was prepared by stirring an excess amount of the test item (100 mg/L) in test medium for up to 24 hours. Then after a filtration (0.22 µm), the aqueous phase (corresponding to the limit of solubility/saturation under our experimental conditions (LS)) was collected and used as a stock solution.
Filtration on filter 0.22 µm was chosen because the certificate of analysis indicates that 50% of the particles constituting the test item are < 0.43 µm.
Test solutions was prepared by further dilution of the stock solution with test medium. For the second definitive test each test solution was prepared by dilution by tow from the higher test solution.
Test vessels were filled directly from the test solution containers after preparation.
The solutions were renewed after 24 hours of exposure.
The pH range considered as appropriate for a normal life of test organisms is circa 6 to 9.
So the pH of the stock solution was measured. The pH of the stock solution was in this range (8,04).
- Test item stock solution preparation:
For the first definitive test, test item stock solution was prepared as follow :
Date Weight (mg): Volume (with test media) Theoretical concentration
mL (chromite de cuivre) mg/l
Chromite de Cuivre,
Batch 09/0117 August 2nd 2010 40,22 400 100,55
BPL10-0008.001 August 3rd 2010 40,38 400 100,95
For the second definitive test, test item stock solution was prepared as follow :
Date Weight (mg): Volume (with test media) Theoretical concentration
mL: (chromite de cuivre) mg/l
Chromite de Cuivre,
Batch 09/0117 August 24th 2010 51,56 500 103,12
BPL10-0008.001 August 25th 2010 49,92 500 99,84
- Test solutions preparation:
For the first definitive test, test solutions were prepared by further dilutions of the test item stock solution (LS) stirred with test media (LS/80 ; LS/40 ; LS/20 ; LS/10 and LS/5).
For the second definitive test, each test solution was prepared by dilution by tow from the higher test solution stirred with test media (LS/16 ; LS/8 ; LS/4 ; LS/2 and LS).
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISMS
- Source: breeding lab
- Age at study initiation (mean and range, SD): between 6 and 24 hours old
- Length at study initiation (length definition, mean, range and SD): between 560 µm and 800 µm
- Method of breeding: produced from parthenogenically reproducing brood female population
- Feeding during test: no data
- Food type: no data
- Amount: no data
- Frequency: no data
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- second definitive test: total hardness was only measured in the controls at the start and the end of the test.
Total Hardness (°F)
Concentration 0H 48H
Control 21,8 22,3 - Test temperature:
- first definitive test: 21.7°C to 22°C
second definitive test: 21.8°C to - pH:
- first definitive test: from 7.61 to 8.98
second definitive test: from 7.86 to 8.04 - Dissolved oxygen:
- first definitive test: 8.34 to 8.90 mg 02/L
second definitive test: 86.2 to 99.9 mg 02/L - Salinity:
- Not measured
- Nominal and measured concentrations:
- Concentrations are expressed in chromite de cuivre by calculation with chromium concentration. The chromium concentration is used because it is the lowest test item concentration (with Cr content calculation from CoA); therefore, it is the worst determination for toxicity test.
See section "any other information on materials and methods. - Details on test conditions:
- TEST SYSTEM
- Renewal rate of test solution (frequency/flow rate): every 24 hours
- No. of organisms per vessel: 5 Daphnids were introduced in each replicates
- No. of vessels per concentration (replicates): 4 replicates per concentration
- No. of vessels per control (replicates): 4 replicates
OTHER TEST CONDITIONS
- Photoperiod: light/dark cycle = 16/8 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mobility inhibition
TEST CONCENTRATIONS
- Test concentrations: For the first definitive test, test solution concentrations were LS/80 ; LS/40 ; LS/20 ; LS/10 and LS/5. For the second definitive test, test solution concentrations were LS/16 ; LS/8 ; LS/4 ; LS/2 and LS). - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.238 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0,223-0,253 mg/l
- Duration:
- 48 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 0.19 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0,18-0,21 mg/l
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.17 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0,16-0,18 mg/l
- Results with reference substance (positive control):
- August 6th, 2010 EC50 = 0,94 mg/L [0,89 – 0,99]
August 20th, 2010 EC50 = 0,94 mg/L [0,89 – 0,99]
Proficiency Test (2 times per year) A.G.L.A.E.
Any other information on results incl. tables
First definitive test
Start of experimentation: August 3rd, 2010 (D0)
End of experimentation: August 5th, 2010 (D2)
Chromite de Cuivre Nominal Concentration (mg/L) |
Mortality Daphnids at 24H * |
Mortality (%) |
|||
A |
B |
C |
D |
||
control |
0 |
0 |
0 |
0 |
0 |
LS/80 |
0 |
0 |
0 |
0 |
0 |
LS/40 |
0 |
0 |
1 |
0 |
5 |
LS/20 |
0 |
0 |
1 |
0 |
5 |
LS/10 |
0 |
1 |
0 |
0 |
5 |
LS/5 |
0 |
0 |
0 |
1 |
5 |
* 5 mobile daphnids per replicate at t=0
Chromite de CuivreNominal Concentration (mg/L) |
Mortality Daphnids at 48H * |
Mortality (%) |
|||
A |
B |
C |
D |
||
control |
0 |
0 |
0 |
0 |
0 |
LS/80 |
0 |
0 |
0 |
0 |
0 |
LS/40 |
1 |
0 |
1 |
0 |
10 |
LS/20 |
0 |
0 |
1 |
0 |
5 |
LS/10 |
0 |
1 |
1 |
0 |
10 |
LS/5 |
1 |
1 |
0 |
2 |
20 |
* 5 mobile daphnids per replicate at t=0
Regarding these results and the normative requirements, the chosen theoretical concentration for the definitive test was LS/16, LS/8, LS/4, LS/2, LS.
Second definitive test
Start of experimentation: August 25th, 2010 (D0)
End of experimentation: August 27th, 2010 (D2)
Chromite de Cuivre initial Concentration (mg/L) |
Mortality Daphnids at 24H * |
Mortality (%) |
|||
A |
B |
C |
D |
||
control |
0 |
0 |
0 |
0 |
0 |
0,156 |
0 |
0 |
0 |
0 |
0 |
0,278 |
0 |
2 |
0 |
0 |
10 |
0,512 |
4 |
5 |
4 |
3 |
80 |
1,092 |
5 |
5 |
5 |
5 |
100 |
2,035 |
5 |
5 |
5 |
5 |
100 |
* 5 mobile daphnids per replicate at t=0
Chromite de Cuivreinitial Concentration (mg/L) |
Mortality Daphnids at 48H * |
Mortality (%) |
|||
A |
B |
C |
D |
||
control |
0 |
1 |
0 |
0 |
0 |
0,156 |
0 |
1 |
0 |
0 |
5 |
0,278 |
3 |
4 |
3 |
4 |
70 |
0,512 |
5 |
5 |
5 |
5 |
100 |
1,092 |
5 |
5 |
5 |
5 |
100 |
2,035 |
5 |
5 |
5 |
5 |
100 |
* 5 mobile daphnids per replicate at t=0
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a 48-hour semi-static acute toxicity test with Daphnia magna, the EC50 of Chromite de Cuivre was 0.238 mg/L.
- Executive summary:
The objective of this study was to assess the acute toxicity of Chromite de cuivre diluted in an aqueous test medium, to a micro-crustacean species, Daphnia magna, in a 48‑hour semi‑static test (definitive test).
Results are described below.
Results according to OECD 202 dated on April 13th, 2004:
Chromite de Cuivre Batch 09/0177
BPL10-0010.001
EC50-48h
0,238 mg/l
Confidence limits (95%)
0,223-0,253 mg/l
EC20-48h
0,19 mg/l
Confidence limits (95%)
0,18-0,21 mg/l
EC10-48h
0,17 mg/l
Confidence limits (95%)
0,16-0,18 mg/l
Legend : EC : Effective Concentration corresponding to the mobility inhibition concentration.
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