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Diss Factsheets
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EC number: 907-961-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Groups of two male and two female Alderley Park SPF albino rats were used, bodyweight range 240-253g for males and 181-203g for females. The animals were fasted for a period of up to 24 hours immediately prior to dosing.
Preparations of the test sample, in corn oil, were then dosed at a standard volume of 10 mL/kg. On Day 1 single doses of 25, 200 and 2000 mg/kg were administered by stomach tube to separate groups of animals. The animals were observed daily up to Day 8 and then on Day 15. At the end of the study the animals were humanely killed by inhalation of excessive levels of halothane BP and were examined by necropsy for any macroscopic abnormalities. The acute oral median lethal dose was estimated from the mortality data. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tridecyl methacrylate
- EC Number:
- 219-671-8
- EC Name:
- Tridecyl methacrylate
- Cas Number:
- 2495-25-2
- Molecular formula:
- C17H32O2
- IUPAC Name:
- tridecyl methacrylate
- Reference substance name:
- Dodecyl methacrylate
- EC Number:
- 205-570-6
- EC Name:
- Dodecyl methacrylate
- Cas Number:
- 142-90-5
- Molecular formula:
- C16H30O2
- IUPAC Name:
- dodecyl methacrylate
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 240-253 g (males), 181-203 g (females)
- Fasting period before study: 24 hours immediately prior to dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 25, 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: dai1y up to Day 8 and then on Day 15
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None of the animals died.
- Clinical signs:
- other: There were no significant signs of toxicity after a single oral dose of 25, 200 or 2000 mg/kg bw.
- Gross pathology:
- No macroscopic abnorma1ities were detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 of Reaction mass of dodecyl methacrylate and tridecyl methacrylate to rat was >2000 mg/kg bw .
- Executive summary:
In an acute oral toxicity study, groups of fasted, young adult Alderley Park SPF albino rats 2/sex/dose were given a single oral dose of Reaction mass of dodecyl methacrylate and tridecyl methacrylate in corn oil at doses of 25, 200 and 2000 mg/kg bw and observed for 15 days.
None of the animals died and there were no significant signs of toxicity.
Oral LD50 Males/Females >2000 mg/kg bw
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