Dimolybdenum trizinc nonaoxide

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Guideline:

other: European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

cascade impaction

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Remarks on result:

not determinable

Remarks:

Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD).

No.:

#1

Size:

< 10 µm

Distribution:

>= 0.081 - <= 0.174 %

No.:

#2

Size:

< 5.5 µm

Distribution:

>= 0 - <= 0.027 %

No.:

#3

Size:

< 2.4 µm

Distribution:

>= 0 - <= 0.027 %

No.:

#4

Size:

< 1.61 µm

Distribution:

>= 0 - <= 0.027 %

No.:

#5

Size:

< 0.307 µm

Distribution:

>= 0 - <= 0.023 %

Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 10 minutes and then sampling from the top, middle and bottom.

Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.

Particle size cut points (µm)	Cumulative mass (g)			Cumulative percentage (%)
	Determination 1	Determination 2	Determination 3	Determination 1	Determination 2	Determination 3
< 10	0.0052	0.0033	0.0023	0.174	0.104	0.081
< 5.5	0.0008	0	0.0001	0.027	0	0.004
< 2.4	0.0008	0	0.0001	0.027	0	0.004
< 1.61	0.0008	0	0.0001	0.027	0	0.004
< 0.307	0.0007	0	0	0.023	0	0

Conclusions:

The percentage of the substance with an inhalable (< 100 µM), thoracic (< 10 µM) and respirable (< 5.5 µM) particle size was determined to be 97.6,

Description of key information

The percentage of the substance with an inhalable (< 100 µM), thoracic (< 10 µM) and respirable (< 5.5 µM) particle size was determined to be 97.6, </= 0.174 and </= 0.027 %, respectively.