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EC number: 232-465-2 | CAS number: 8047-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: pre-GLP
Data source
Reference
- Reference Type:
- other: Certificate of analysis
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: Not specified
Test material
- Reference substance name:
- N-ethyl-o(or p)-toluenesulphonamide
- EC Number:
- 232-465-2
- EC Name:
- N-ethyl-o(or p)-toluenesulphonamide
- Cas Number:
- 8047-99-2
- Molecular formula:
- C9H13NO2S
- IUPAC Name:
- N-ethyl-4-methylbenzene-1-sulfonamide
- Test material form:
- liquid: viscous
- Remarks:
- Colour: light yellow
- Details on test material:
- Ketjenflex 8 (NETSA)
Chemical name in report: N-ethyl-o/p-toluenesulfonamide (or N-substituted toluene sulphonamide)
Description: light yellow viscous liquid
Purity 100% (or 90%)
Test substance storage: at room temperature in the dark
Stability under storage conditions: stable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Initial weight:
- Male: 1.9 kg
- Female: 1.8 and 2.2
Details on other conditions and test animal was not provided
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Applied undiluted
- Details on dermal exposure:
- Information not provided
- Duration of exposure:
- 24 hours
- Doses:
- 5,010 and 7,940 Mg/Kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no information
- Necropsy of survivors performed: no information
- Other examinations performed: signs of intoxication, gross autopsy decedents, survivors - Statistics:
- No information
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Reduced appetite and activity ( three to five days)
- Other findings:
- Survivors ( 14 days): Viscera appeared normal
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- according to the EU classification criteria outlined in Annex I of 1272/2008/EC (CLP)
- Conclusions:
- The LD50 of Santicizer 8 in rabbits after 24 hours was > 7940 mg/kg bw under the conditions of this test.
- Executive summary:
To determine the dermal toxicity of Santicizer 8, an acute dermal toxicity study was performed on three New Zealand albino rabbits at a dosage level of 5010 and 7940 mg/kg bw. The LD50 of the test substance after 24 hours was > 7940 mg/kg bw under the conditions of this test. Santicizer 8 therefore does not have to be classified for acute dermal toxicity.
As a result, the substance N-Ethyl-o (or p)-toluenesulfonamide (NETSA) does not need to be classified for acute dermal toxicity according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).
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