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EC number: 948-020-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 September 2017 to 7 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Specific details on test material used for the study:
- -Purity: >99% (UVCB)
-Description: Amber Clear Liquid - Test temperature:
- 30 °C (Column temperature)
- Details on study design: HPLC method:
- Preparation of sample solution - Test Substance Stock
A 10 mg/mL of the test material primary stock solution was prepared by bringing 0.0992 g (tested as 100%) of the test stubstance to a final volume of 9.92 mL with methanol.
This stock solution was stored in a freezer in a clear glass bottle with Teflon-lined cap. A 1 mg/mL secondary stock solution was prepared by bringing 1 mL of the 10 mg/mL primary stock solution to a volume of 10 mL with methanol.
Mobile phase flow rate: 1.0 mL/min
UV wavelength: 210 and 240 nm - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 7.62 dimensionless
- Matrix:
- soil
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- ca. 8.23 dimensionless
- Matrix:
- soil
- Key result
- Sample No.:
- #3
- Type:
- log Koc
- Value:
- ca. 8.71 dimensionless
- Matrix:
- soil
- Key result
- Sample No.:
- #4
- Type:
- log Koc
- Value:
- ca. 9.25 dimensionless
- Matrix:
- soil
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 7.57 dimensionless
- Matrix:
- sludge
- Key result
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- ca. 8.16 dimensionless
- Matrix:
- sludge
- Key result
- Sample No.:
- #3
- Type:
- log Koc
- Value:
- ca. 8.62 dimensionless
- Matrix:
- sludge
- Key result
- Sample No.:
- #4
- Type:
- log Koc
- Value:
- ca. 9.14 dimensionless
- Matrix:
- sludge
- Details on results (HPLC method):
- The log Koc values of the test material in soil and sludge ranged from 7.62 to 9.25 and from 7.57 to 9.14, respectively.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc values of the test material in soil and sludge ranged from 7.62 to 9.25 and from 7.57 to 9.14, respectively.
- Executive summary:
The objective of this study was to determine the adsorption coefficient (Koc) for the test material. The study has been performed to the standardized guideline OECD 121, under GLP conditions.
The adsorption distribution coefficient (Kd) is the ratio of the concentration of the test substance in the soil (Cs) and the concentration of the test substance in the aqueous phase (Caq) at the point of equilibrium. The adsorption coefficient (Koc) is the adsorption distribution coefficient (Kd) normalized with the organic carbon content of the soil (foc). A series of reference substances with well-characterized partition coefficients were injected onto the analytical column which was then followed by an injection of the test substance. The retention of each reference substance injected onto such a column is proportional to the adsorption coefficient of that substance, with water-soluble chemicals eluting first and oil-soluble chemicals last. The adsorption coefficient of the test substance was derived from the retention factor (k), using a calibration plot of log k versus log Koc of the reference substances.
The mean retention times of the four major components comprising the test material were approximately 25.9, 34.5, 43.5, and 56.5 minutes.
The mean log Koc values determined for these components for soil and sludge ranged from 7.62 (Koc 41,668,651) to 9.24 (Koc 1,731,122,699) and from 7.57 (Koc 37,197,330) to 9.13 (Koc ,1,343,255,426) respectively, which were calculated by extrapolation from the calibration curves. The duplicate log Koc values for each major constituent in the test material were considered acceptable since they fell within a range of ± 0.25 log units.
Reference
The mean retention times of the four major components of the test material approximately 25.9, 34.5, 43.5, and 56.5 minutes. The mean log Koc values determined for these components for soil and sludge ranged from 7.62 (Koc 41,668,651) to 9.24 (Koc 1,731,122,699) and from 7.57 (Koc 37,197,330) to 9.13 (Koc ,1,343,255,426) respectively, which were calculated by extrapolation from the calibration curves. The duplicate log Koc values for each major constituent in reaction products of 2,5-dimercapto-1,3,4-thiadiazole, sodium salt, with 1-octanethiol and hydrogen peroxide were considered acceptable since they fell within a range of ± 0.25 log units.
Description of key information
The objective of this study was to determine the adsorption coefficient (Koc) for the test material. The study has been performed to the standardized guideline OECD 121, under GLP conditions. The mean retention times of the four major components comprising the test material were approximately 25.9, 34.5, 43.5, and 56.5 minutes. The mean log Koc values determined for these components for soil and sludge ranged from 7.62 (Koc 41,668,651) to 9.24 (Koc 1,731,122,699) and from 7.57 (Koc 37,197,330) to 9.13 (Koc ,1,343,255,426) respectively, which were calculated by extrapolation from the calibration curves. The duplicate log Koc values for each major constituent in the test material were considered acceptable since they fell within a range of ± 0.25 log units.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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