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EC number: 428-190-4 | CAS number: 68490-66-4 CUREZOL 2MA-OK
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 May - 07 Jul 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
Test material
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Remarks:
- CO2-free air
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Worlingworth sewage treatment works treating predominantly domestic waste
- Initial cell/biomass concentration: 30 mg/L suspended solids concentration - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- other: Carbon
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral salts medium according to guideline
- Test temperature: 20.1 - 24.0 °C
- pH: 7.5 - 7.6
- pH adjusted: No
- Aeration of dilution water: Air-saturated ultrapure water was used to prepare the mineral salts medium.
- Suspended solids concentration: 30 mg/L
TEST SYSTEM
- Culturing apparatus: 5 L vessels
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: Aeration with CO2-free air (air was passed through cylinders containing fused calcium chloride and Carbosorb AS)
- Details of trap for CO2 and volatile organics if used: 3 Dreschel bottles in series, connected to the outlets of every test vessels, each containing barium hydroxide
SAMPLING
- Sampling frequency: Day 2, 4, 6, 7, 8, 11, 14, 21, 28, 29
- Other: The residual concentrations of barium hydroxide in the bottles nearest to the test vessels were determined at intervals by duplicate titration of 20 mL samples with hydrochloric acid (0.05 N), using phenolphthalein indicator. Following the removal of the first Dreschel bottle in the series of 3, the second was connected to the test vessel and the bottle containing fresh barium hydroxide was connected to the outlet of the bottle at the end of the series. On Day 28 of the test, titrations were performed and then concentrated hydrochloric acid (1 mL) was added to each vessel to drive off dissolved organic carbon. The contents of the vessels were aerated overnight and the final titrations were carried out on Day 29.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 replicates (mineral salts medium + inoculum)
- Reference compound: 1 replicate (mineral salts medium + inoculum + 10 mg C/L sodium benzoate)
- Toxicity control: 1 replicate (mineral salts medium + inoculum + 10 mg C/L sodium benzoate + 10 mg C/L test item)
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 29 d
- Details on results:
- The cumulative CO2 production of the vessels containing the test item was negligible by the end of the test on Day 29.
The degradation of the reference compound sodium benzoate was rapid and reached 62% of its ThCO2 after 7 d and 77% after 29 d.
The degradation of the reference compound was also rapid in the presence of the test item and reached 65% of its ThCO2 after 7 d.
Any other information on results incl. tables
VALIDITY CRITERIA
The inoculum and toxicity controls confirmed the suitability of the test and inoculum.
The study fulfills the validity criteria of this test (Table 1).
Table 1: Validity criteria for OECD 301 B.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
Difference of extremes of replicate values of the removal of the test chemical at the plateau, at the end of the test or at the end of the 10-d window, as appropriate, is less than 20%. |
The difference of extremes was < 20%. |
Yes |
Percentage degradation of the reference compound has reached the pass levels by day 14. |
Percentage degradation of the reference compound is 71% on Day 14. |
Yes |
The toxicity control should degrade to at least 35% (based on DOC) or at least 25% (based on ThOD or ThCO2) within 14 d. |
The toxicity control degraded by 65% on Day 7. |
Yes |
The IC content of the test substance suspension in the mineral medium at the beginning of the test must be less than 5% of the TC. |
data not reported
|
|
The total CO2 evolution in the inoculum blank at the end of the test should not normally exceed 40 mg/L medium. |
data not reported |
|
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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