Registration Dossier
Registration Dossier
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EC number: 208-831-2 | CAS number: 542-85-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- A QSAR model was used to estimate the LC50 for ethyisothiocyanate and was published as an attachment
Data source
Reference
- Reference Type:
- publication
- Title:
- Ethylisothiocyanate - Short term aquatic toxicity on invertebrates
- Author:
- Ohe, Kuhne
- Year:
- 2 005
- Bibliographic source:
- Chem Res Toxicol 18 (3) 536-555
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- Quantitative and qualitative structure-activity relationships (QSARs)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl isothiocyanate
- EC Number:
- 208-831-2
- EC Name:
- Ethyl isothiocyanate
- Cas Number:
- 542-85-8
- Molecular formula:
- C3H5NS
- IUPAC Name:
- ethyl isothiocyanate
- Test material form:
- liquid
Constituent 1
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: Log LC50
- Effect conc.:
- -5.31 mol/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- not specified
- Remarks on result:
- other: based on LogLC50
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Ethylisothiocyanate is expected to be very toxic to aquatic invertabrates based on a QSAR study
- Executive summary:
Ethylisothiocyanate is expected to be very toxic to aquatic invertabrates based on a QSAR study
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