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EC number: 500-344-6 | CAS number: 157627-94-6 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data are available for the target substance Alcohols, C12-14, ethoxylated (1-2.5 EO), sulfates, triethanolammonium salts (CAS 157627-94-6). Therefore, read-across from structural analogue substances has been applied.
skin sensitization (OECD 406): not sensitizing
Read-across from structural analogue source substances Alcohols, C12-14, ethoxylated, sulfates, sodium salts (CAS 68891-38-3) and C12-C14 fatty alcohol polyethylene glycol (2EO) ether suphate, triisopropanolammonium salt (CAS 174450-50-1).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- No positive control.
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Test was done before LLNA as first-choice method for in-vivo testing was set into force.
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- According to Guideline.
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 50%
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 25%
- No. of animals per dose:
- 20 (test group)
10 (control group) - Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Group:
- positive control
- Remarks on result:
- other: no information on positive control group given in study report
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- GPMT
- Deviations:
- yes
- Remarks:
- No positive control.
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Test was done before LLNA as first-choice method for in-vivo testing was set into force.
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- According to Guideline.
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- Intradermal: 0.05%
Epicutaneous: 2.5 % - Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 0.1 and 0.5%
- No. of animals per dose:
- 20 (test group)
10 (control group) - Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.1%
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.1%
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5%
- No. with + reactions:
- 6
- Total no. in group:
- 20
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5%
- No. with + reactions:
- 5
- Total no. in group:
- 20
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.5%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.5%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Group:
- positive control
- Remarks on result:
- other: no information on positive control group given in study report
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Referenceopen allclose all
No information on positive control group given in study report.
No information on positive control group given in study report.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data on skin sensitisation are available for AES (C12-14; 1-2.5 EO) C6H15NO3 (CAS 157627-94-6). Therefore, this endpoint is covered by read-across from structurally related AES. The AES reported within the category show similar structural, physico-chemical, environmental and toxicological properties. The approach of grouping different AES for the evaluation of their effects on human health and the environment was also made by the Danish EPA (2001) and HERA (2003), supporting the read-across approach between structurally related AES.
Skin sensitization
There are two studies available addressing skin sensitisation for the analogue substances AES (C12-14; 1-2.5 EO) Na (CAS 68891-38-3) and AES (C12-14; 1-2.5 EO) TIPA (CAS 174450-50-1). Both studies are accounted for in a Weight-of-Evidence approach.
The skin sensitizing potential was assessed with AES (C12-14; 2 EO) Na (CAS 68891-38-3) in a Guinea Pig Maximisation Test according to OECD Guideline 406 (Unger Fabrikker, 1986b). In this study 20 female guinea pigs were induced by intradermal and epicutaneous application of the test item at concentrations of 0.05% (intradermal induction) and 2.5% (epicutaneous induction). Challenge was performed with 0.1 and 0.5%. Water was used as vehicle. At a dose level of 0.1% 1/20 (5%) animals treated with the test item and 1/10 (10%) animals of the control group showed a positive reaction at reading 24 and 48 h after challenge. At the dose level of 0.5% 6/20 animals (30%) after 24 h and 5/20 animals (25%) after 48 h showed a positive response. In the control group 2 of 10 animals (20%) showed a positive response at the 24 and 48 h reading. Thus, the test item showed no significant sensitising potential within this study.
A second study on skin sensitisation was performed with AES (C12-14; 2 EO) TIPA (CAS 174450-50-1) in a Buehler Test on 20 Dunkin-Hartley guinea pigs according to OECD guideline 406 (Sasol, 1997d). The induction was performed with 50% of the test substance and the challenge with 25% of the test substance. Both applications were conducted under occlusive conditions and water was used as vehicle. At both readings (24 and 48 h after challenge) 0/20 animals of the test group and 0/10 animals of the control group showed a positive response. Thus, the test item showed no significant sensitising potential within this study.
No sensitising potential of the substance is expected based on the above mentioned data. This is also supported by the evaluation of various AES reported in the HERA report (2003).
Influence of counter ions on sensitizing potential
Since triethanolamine (TEA) in its protonated form (triethanolammonium) is the counter-ion present in Alcohols C12-14, ethoxylated (1-2,5 EO) sulphated, trieth salts (CAS 157627-94-6), TEA might have an impact on the toxicological properties of the registered substance. Therefore, the toxicological profile of TEA is considered. TEA is not listed in Annex VI of Regulation 1272/2008. In addition, the effects of TEA on human health were assessed by the OECD in the SIDS initial assessment Report (2013). Despite of some local signs of irritation TEA gives no rise to concern of adverse effects on human health. Therefore, contribution of TEA to the endpoint sensitization of AES is not expected.
References:
Danish EPA - Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products (2001). Environmental Project No. 615, pp. 24-28
HERA (2003). Human & Environmental Risk Assessment on ingredients of European household cleaning products Alcohol Ethoxysulphates, Human Health Risk Assessment Draft, 2003. http: //www. heraproject. com.
SIDS initial assessment report, (2013); http://webnet.oecd.org/HPV/UI/SIDS_Details.aspx?key=8aefe41b-8499-4052-943f-f6dd6f8c5997&idx=0
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Study not required according to Annex VII-X of Regulation (EC) No. 1907/2006.
Justification for classification or non-classification
The available data on skin sensitisation do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP) and are therefore conclusive but not sufficient for classification. No data are available for respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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