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Registration Dossier
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Diss Factsheets
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EC number: 256-589-1 | CAS number: 50448-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not sufficiently detailed study suffering severe limitations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 947
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In this old study (study conducted largely before the date of publication of the OECD Guidelines relevant for this endpoint), animals were exposed intraperitoneally to test substance at 6 different concentrations and were only observed for mortality.
When compared to standard acute toxicity studies, this study suffers various limitations: only males were dosed; the observation period was only 7 days; the protocol was poorly described; the equipment used was not detailed; the analytical monitoring was not performed and animals were only observed for determinig the mortality rate. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl mercaptoacetate
- EC Number:
- 231-626-4
- EC Name:
- 2-ethylhexyl mercaptoacetate
- Cas Number:
- 7659-86-1
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-ethylhexyl sulfanylacetate
- Details on test material:
- - Name of test material (as cited in study report):
Thioglycolate de 2-ethyle hexyle
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- arachis oil
- Doses:
- 0.8, 1.0, 1.2, 1.4, 1.5, 1.6 mL/kg (corresponding to approximately 0.78, 0.97, 1.17, 1.36, 1.46, 1.56 g/kg bw based on a reported density of 0.972
g/mL) - No. of animals per sex per dose:
- 10 animals in 0.8-, 1.0- and 1.6-mL/kg treatment groups; 20 animals in the other treatment groups.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.36 mL/kg bw
- 95% CL:
- 1.33 - 1.39
- Remarks on result:
- other: LD50 equivalent to 1320 mg/kg bw
Any other information on results incl. tables
Table of mortality
Tested concentration (mL/kg) |
Mortality |
|
Number of animals |
Rate (%) |
|
0.8 |
0/10 |
0 |
1.0 |
0/10 |
0 |
1.2 |
3/20 |
15 |
1.4 |
10/20 |
50 |
1.5 |
15/20 |
70 |
1.6 |
10/10 |
100 |
Applicant's summary and conclusion
- Conclusions:
- By intraperitoneal administration, the LD50 was estimated to be 1320 mg/kg bw in mouse.
- Executive summary:
In this old study, groups of 10 to 20 male swiss mice were given the substance at 0.8 to 1.6 mL/kg by intraperitoneal injection. The LD50 was found to be 1.36 ml/kg bw, equivalent to 1320 mg/kg bw, based on the density of the substance of 0.972 mL/g.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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