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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS: Ammonium, (9-(o-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride
Author:
unknown
Year:
1961
Bibliographic source:
RTECS number BP3675000 citing TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-1959- Volume(issue)/page/year:3,696,1961

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no information on the method
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
EC Number:
201-383-9
EC Name:
9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
Cas Number:
81-88-9
Molecular formula:
C28H31N2O3.Cl
IUPAC Name:
9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
12 weeks
Frequency of treatment:
not specified
Doses / concentrations
Dose / conc.:
50 400 other: mg/kg/12W-C
No. of animals per sex per dose:
not specified
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Description (incidence and severity):
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Gross pathological findings:
not specified
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified

Effect levels

Dose descriptor:
dose level: TDLo (Lowest published toxic dose)
Effect level:
ca. 50 400 other: mg/kg/12W-C
Based on:
test mat.
Sex:
not specified
Basis for effect level:
body weight and weight gain
organ weights and organ / body weight ratios

Target system / organ toxicity

Key result
Critical effects observed:
no

Applicant's summary and conclusion

Conclusions:
Basic violet 10 was administered by oral route to rats for 12 weeks.
Some effects were observed: changes in liver weight and bladder weight, weight loss or decreased weight gain.
The Lowest published toxic dose (TDLo) was 50400 mg/kg/12W-C.
No further information was provided.