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Diss Factsheets
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EC number: 200-372-6 | CAS number: 58-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No raw data are included (calculated LD values only). No data on the number of animals per dose group. No data on clinical signs or gross pathology.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mice were exposed to five concentrations of test substance on five consecutive days. Mortalities were recorded daily during the dosing and 10 days after the last dose. Body weight was measured before the first dose and 24h after the 5th dose.
- GLP compliance:
- no
- Test type:
- other: no details on study design
- Limit test:
- no
Test material
- Reference substance name:
- Menadione
- EC Number:
- 200-372-6
- EC Name:
- Menadione
- Cas Number:
- 58-27-5
- Molecular formula:
- C11H8O2
- IUPAC Name:
- 2-methyl-1,4-dihydronaphthalene-1,4-dione
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Animals were exposed on 5 consecutive days and observed for 10 days after the last dose.
- Doses:
- 125; 250; 600; 1000; 2000 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Statistics:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 030 mg/kg bw
Any other information on results incl. tables
The mortalities are given in the table below, number of animals is not specified. No difference in body weight gain was observed between the groups from the beginning of the study to day 6, when the weights were recorded.
Dose (mg/kg) |
Day 1 |
2000 |
100% |
1000 |
40% |
500 |
0% |
250 |
0% |
125 |
0% |
Derived LD50 (mg/kg) |
1030 ± 165* |
* 24h after the 1stdose
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 is 1030 ± 165 mg/kg.
- Executive summary:
The acute oral toxicity of menadione was tested in mice. The LD50 is 1030 ± 165 mg/kg, as determined 24h after the first dose.
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