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EC number: 948-034-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to the Read-across statement attached under section 13.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This Read-Across is based on the hypothesis that the target and the source substances have similar environmental fate and (eco)toxicological properties, because both substances have the same common compound octyl sulfonate while another main constituent of the target substance octyl disulfonate is considered to have similar level of toxicity as octyl sulfonate. Other non-common compounds represented by impurities are considered not to influence the read-across validity because they are either structurally identical in the target and in the source substances or, if different, do not contribute to the toxicity effects because they are also anionic sulfonates with the same functional groups and their content is very low.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Please refer to the Read-across statement attached under section 13.
3. ANALOGUE APPROACH JUSTIFICATION
The aquatic toxicity of the ANS category members is influenced mainly by the length of alkyl chain. Numerous studies demonstrate increasing toxicity with the chain length. Since all sulfonate containing constituents of the target substance are octyl derivatives, they are considered not to possess higher toxicity potential to aquatic environment than the source substance. Taking into account the similar predicted environmental fate and behavior as well as the similar mode of ecotoxic action due to its surfactant properties, the second sulfonate group of the main constituent octyl disulfonate is considered not to result in a higher toxicity to aquatic life than the source substance. Thus, the results of the acute toxicity study in aquatic invertebrates available for the source substance are considered to be the same if a study with the target substance was conducted.
4. DATA MATRIX
Please refer to the Read-across statement attached under section 13. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 421 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% Confidence Interval: 372 - 472 mg/L
- Remarks:
- predicted result from the source substance
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: predicted result from the source substance
- Details on results:
- Daphnia in the negative control group appeared normal throughout the test, with no mortality/immobility or clinical signs of toxicity observed throughout the test. All daphnids in the 65 mg/L treatment group also appeared normal throughout the test, with no mortality/immobility or overt signs of toxicity observed. All daphnids in the 108 and 180 mg/L treatment groups appeared normal throughout the test, with the exception of two lethargic daphnid noted in each of these treatment groups at test termination. Percent mortality/immobility at test termination in the 300 and 500 mg/L treatment groups were 5 and 80%, respectively. All surviving daphnids in the 300 and 500 mg/L treatment groups were lethargic at test termination.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The same result is predicted for the target substance.
The cladoceran, Daphnia magna, was exposed for 48 hours under static conditions to five nominal concentrations of the source substance sodium octane-1-sulphonate monohydrate (EC 226 -195 -4; CAS 5324 -84 -5) ranging from 65 to 500 mg/L. The 48-hour EC50 value was 421 mg/L, with a 95% confidence interval of 372 to 472 mg/L. The slope of the concentration-response curve was 11.212. - Executive summary:
The objective of this study was to determine the acute effects of the source substance sodium octane-1-sulphonate monohydrate (EC 226 -195 -4; CAS 5324 -84 -5) on the cladoceran, Daphnia magna. The protocol was based on procedures outlined in the OECD Guideline for Testing of Chemicals, 202: Daphnia sp. Acute Immobilization Test and Reproduction Test. The study was performed under GLP conditions with deviations. Daphnia magna, was exposed for 48 hours under static conditions to five nominal concentrations ranging from 65 to 500 mg/L. The EC50 (48 h) value was 421 mg/L, with a 95% confidence interval of 372 to 472 mg/L. The slope of the concentration-response curve was 11.212.
Reference
Table 2: Cumulative Mortality, Immobility and Observations |
|||||||||||||
Nominal Test Concentration (mg/L) |
Replicate |
Daphnia/Replicate |
5 Hours |
24 Hours |
48 Hours |
Percent Immobile and Dead |
|
||||||
Number Dead1
|
Number Immobile |
Effects2 |
Number Dead1 |
Number Immobile |
Effects2 |
Number Dead1 |
Number Immobile |
Effects2 |
|||||
Negative Control |
A |
10 |
0 |
0 |
10 AN |
0 |
0 |
10AN |
0 |
0 |
10AN |
0 |
|
B |
10 |
0 |
0 |
10AN |
0 |
0 |
10AN |
0 |
0 |
10AN |
|||
65 |
A |
10 |
0 |
0 |
10AN |
0 |
0 |
6AN; 4Q,AN |
0 |
0 |
10AN |
0 |
|
B |
10 |
0 |
0 |
8AN; 2Q,AN |
0 |
0 |
6AN; 4Q,AN |
0 |
0 |
10AN |
|||
108 |
A |
10 |
0 |
0 |
10AN |
0 |
0 |
5AN; 5Q,AN |
0 |
0 |
10AN |
0 |
|
B |
10 |
0 |
0 |
10AN |
0 |
0 |
7AN; 3Q,AN |
0 |
0 |
8AN; 2C |
|||
180 |
A |
10 |
0 |
0 |
8AN; 2QAN |
0 |
0 |
4AN; 6Q,AN |
0 |
0 |
9AN;1Q.AN |
0 |
|
B |
10 |
0 |
0 |
10AN |
0 |
0 |
5AN; 4Q,AN; 1C |
0 |
0 |
8AN; 2Q,C |
|||
300 |
A |
10 |
0 |
0 |
10AN |
0 |
0 |
6AN; 4Q,AN |
1 |
0 |
1Q,C; 8C |
5 |
|
B |
10 |
0 |
0 |
9AN; 1Q,AN |
0 |
0 |
8AN; 2Q,AN |
0 |
0 |
10C |
|||
500 |
A |
10 |
0 |
0 |
10AN |
0 |
0 |
2Q,C; 8C |
6 |
0 |
4C |
80 |
|
B |
10 |
0 |
0 |
10AN |
0 |
0 |
1Q,C; 9C |
10 |
0 |
---- |
|||
1 Cumulative number of dead daphnia. 2 Observed Effects: AN = appear normal; Q,AN = trapped at water surface but appear normal after submersion below the water's surface; Q,C = trapped at water surface and appearlethargic after submersion below the water's surface; C = lethargy. |
|
Description of key information
Read-across: OECD 202, GLP, D. magna, EC50 (48 h) = 421 mg/L (nominal)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 421 mg/L
Additional information
The objective of this study was to determine the acute effects of sodium octane-1-sulphonate monohydrate (EC 226 -195 -4; CAS 5324 -84 -5) on the cladoceran Daphnia magna.The protocol was based on procedures outlined in the OECD Guideline for Testing of Chemicals, 202: Daphnia sp. Acute Immobilization Test and Reproduction Test. The study was performed under GLP conditions with deviations.Daphnia magna was exposed to five nominal concentrations ranging from 65 to 500 mg/L under static conditions for 48 hours.
The EC50 (48 h) value was 421 mg/L, with a 95 % confidence interval of 372 to 472 mg/L. The slope of the concentration-response curve was 11.212.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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