Registration Dossier
Registration Dossier
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EC number: 272-249-5 | CAS number: 68784-47-4
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Objective of study:
- other: Assessment of toxicokinetic behaviour
- Qualifier:
- according to guideline
- Guideline:
- other: Assessment of degradation products
- GLP compliance:
- no
- Metabolites identified:
- no
Reference
Testing has been performed to confirm the degradation of the substance in diluted solutions in water and it is confirmed that in common with the range of organo-titanium complexes of this nature, there will be rapid degradation (30 minutes) with reversion back to starting materials.
These abiotic degradation products have been identified as:
Propan-2-ol
triisopropanolamine
Propylene glycol
Ethylene glycol
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
If swallowed, the substance will quickly hydrolyse to titanium dioxide, triisopropanolamine, propan-2-ol and ethylene glycol. None of these substances are classified as hazardous and although some pH effects from contact with the amine may result in local irritation, this has not been reported from testing.
The substance is a viscous liquid with minimal risk of inhalation. If on contact with skin, it is likely that there will be exposure to the degradation products; none of these are considered harmful to the skin.
From public documents, the organic degradation products will themselves be readily metabolised if ingested and there is little evidence that the titanium dioxide will be absorbed.
For the IUCLD endpoints, a read-across titanate has been cited for some of the endpoints, but other references have also been added.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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