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EC number: 220-518-2 | CAS number: 2788-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Type: mixed population of aquatic microorganisms (activated sludge)
- Origin: aeration tank of a wastewater plant treating predominantly domestic sewage (Wupper area water authority, WWTP Odenthal)
- Date of collection: 2017-04-18
- Concentration of inoculum: 30 mg/L suspended solids
Pre-treatment of the inoculum
− Before use, the inoculum was stored for two days at room temperature under continuous stirring with aeration.
− The sludge was washed twice by adding mineral medium and centrifuging for 10 min at 2000 rpm and 20 °C and decanting off the supernatant.
− An aliquot of the wet sludge was dried in order to determine the wet weight / dry weight ratio of the sludge and to prepare a stock suspension (activated sludge) of 3 g dw/L.
− The calculated amount of sludge, needed to achieve 300 mL of this stock suspension, was dissolved in mineral medium and then filled up to a defined end volume. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Pre-treatment of the test item:
- 25 mg of the test item were weighed on aluminum foil and added to the test flasks, filled with 200 mL of mineral medium
- volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg test item/L
Pre-treatment of the reference compound
- 25 mg of the reference compound sodium benzoate were weighed on aluminum foil and added to the test flasks, filled with 200 mL of mineral medium
- volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg reference compound /L
Pre-treatment of the toxicity control
- 25 mg of the test item and 25 mg of the reference compound were weighed on aluminum foil and added to the test flasks, filled with 200 mL of mineral medium
- flask volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg test item and reference compound/L
Exposure conditions
- Test volume: 250 mL
- Test apparatus: OxiTopControl System (WTW)
- Mixing: 1 magnetic stirrer per test vessel
- Incubation time: 28 days
- Incubation temperature: 22 ± 1 °C - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Acros Organics, purity 99.9 %, batch no. A0357641
- Parameter:
- % degradation (O2 consumption)
- Value:
- 13
- Sampling time:
- 28 d
- Details on results:
- 5 % degradation after 7 days
9 % degradation after 14 days
12 % degradation after 21 days - Validity criteria fulfilled:
- yes
- Remarks:
- biodegradability reference compound ≥ 60 % 14 d; degradation of toxicity control > 25 % 14 d; end of test, at plateau or end of the 10-d window, biodegradation in parallels (test item) differ < 20 %; oxygen uptake blank ≤ 60 mg/L; pH independent
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- For dimethyl (dimethoxyphosphinyl)succinate a degradation of 13 % was determined after 28 d. Therefore, dimethyl (dimethoxyphosphinyl)succinate is considered to be “Not Readily Biodegradable“.
- Executive summary:
This study was designed to assess the ready biodegradability of dimethyl (dimethoxyphosphinyl)succinate and conducted in accordance with the Council Regulation (EC) No 440/2008, Method C.4-D “Manometric Respirometry Test“(2008). This test method is in all essential parts identical with OECD Guideline 301 F (adopted July 1992).
A suspension of dimethyl (dimethoxyphosphinyl)succinate in a mineral medium was inoculated and incubated at a constant temperature (22 ± 1 °C) for 28 d under aerobic conditions in the dark. During this period, degradation was followed by continuous automated BOD determinations.
Tests with dimethyl (dimethoxyphosphinyl)succinate were run in triplicate as well as the blank control (inoculum but without test item). A reference compound (sodium benzoate) was run parallel in duplicate to check the operation of the procedures.
A toxicity control (test item and reference compound mixed, one replicate) was run in parallel, to ensure that the chosen concentration of the test item was not inhibitory to microorganisms.
Dimethyl (dimethoxyphosphinyl)succinate showed 13 % degradation after 28 days. Therefore, dimethyl (dimethoxyphosphinyl)succinate is considered to be “Not Readily Biodegradable“.
The reference compound sodium benzoate showed 94 % degradation after 14 days.
Reference
Description of key information
A study was designed to assess the ready biodegradability of dimethyl (dimethoxyphosphinyl)succinate and conducted in accordance with the Council Regulation (EC) No 440/2008, Method C.4-D “Manometric Respirometry Test“(2008).
For dimethyl (dimethoxyphosphinyl)succinate a degradation of 13 % was determined after 28 d. Therefore, dimethyl (dimethoxyphosphinyl)succinate is considered to be “Not Readily Biodegradable“.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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