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EC number: 270-151-7 | CAS number: 68411-85-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In-Vivo Skin Irritation - Not Irritating for rabbit (equivalent or similar to U.S. Federal Hazardous Substances Act Consumer Product Safety Commission16 CFR § 1500.41 - Method of testing primary irritant substances)
Acute Dermal Toxicity - Not Irritating for rabbit (OECD TG 402)
In-Vivo Eye Irritation - Not irritating for rabbit (equivalent or similar to U.S. Federal Hazardous Substances Act Consumer Product Safety Commission 16 CFR § 1500.42- Test for eye irritants/ OECD TG 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 02 March 1978 - 12 April 1978
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- ; Dermal reactions noted as part of Acute Dermal LD50 study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: The method of testing the dermal toxicity of the test substance is a patch-test technique on the abraded and intact skin of the New Zealand White rabbit, clipped free of hair. The animals were observed daily for 14 days for clinical signs of toxicity and mortality, and once on Day 1 for skin reactions.
- Short description of test conditions: Twelve New Zealand White Rabbits were clipped free of abdominal hair. Epidermal abrasions were made longitudinally every 2 to 3 cm over the exposed area on even numbered rabbits. The abrasions were sufficiently deep to penetrate the stratum corneum but not deep enought to produce bleeding. The area was covered with gauze and the trunk was wrapped with impervious material for 24 hours. At 24 hours, the rabbits were cleansed and dermal reactions were evaluated by the Draize technique.
- Parameters analysed / observed: Erythema and edema were evaluated at 24 hours post application. - GLP compliance:
- no
- Remarks:
- Study predates GLP
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mobil Chemical Company (Edison NJ) Lot# CRU 1086
- Expiration date of the lot/batch: not specified
- Purity test date: not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability under test conditions: not specified
- Solubility and stability of the test substance in the solvent/vehicle: not applicable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not applicable - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animals and environmental conditions not provided
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5.0 g/kg and 10.0 g/kg - Duration of treatment / exposure:
- Epidermal abrasions were made longitudinally every 2 to 3 cm over the exposed area on even numbered rabbits. The abrasions were sufficiently deep to penetrate the stratum corneum but not deep enought to produce bleeding. The area was covered with gauze and the trunk was wrapped with impervious material for 24 hours.
- Observation period:
- The animals were observed daily for 14 days for clinical signs of toxicity and mortality, and once on Day 1 for skin reactions.
- Number of animals:
- 5.0 g/kg- 4 rabbits; 10.0 g/kg - 8 rabbits
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1.75
- Max. score:
- 2
- Reversibility:
- other: Observations of skin reactions terminated at 24 hours
- Remarks on result:
- other: 5.0 g/kg
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: Observations of skin reactions terminated at 24 hours
- Remarks on result:
- other: 5.0 g/kg
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1.75
- Max. score:
- 3
- Reversibility:
- other: Observations of skin reactions terminated at 24 hours
- Remarks on result:
- other: 10.0 g/kg
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0.875
- Max. score:
- 3
- Reversibility:
- other: Observations of skin reactions terminated at 24 hours
- Remarks on result:
- other: 10.0 g/kg
- Interpretation of results:
- other: Not Irritating
- Conclusions:
- Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone did not produce evidence of primary skin irritation or corrosion in an in-vivo assay. These findings do not meet OECD testing criteria necessary for classification. However, this study should only be used as supporting information due to the limited range of observations and documentation.
- Executive summary:
The primary dermal irritation potential for Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone was evaluated by application of 5.0 and 10.0 g/kg test material to the intact and abraded skin of 12 albino rabbits in an acute dermal toxicity study. Mild erythema and edema was observed at 24 hours at bose dose levels. However, due to the limited documentation and deviations from OECD skin irritation testing guidelines such as longer exposure duration (24 hours), occlusive dressing, and abraded skin, this study should only be used as supporting information.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 April 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- ; 24 hour exposure, occlusive dressing, abraded and non-abraded skin
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. Federal Hazardous Substances Act Consumer Product Safety Commission16 CFR § 1500.41 - Method of testing primary irritant substances
- Version / remarks:
- Formerly U.S. Federal Hazardous Substances Act Food and Drug Commission 21 CFR § 191.11
- Principles of method if other than guideline:
- - Principle of test: The method of testing the dermal corrosivity and primary irritation of substances referred to in § 1500.3(c)(3) and (4), respectively, is a patch-test technique on the abraded and intact skin of the albino rabbit, clipped free of hair. An equal number of exposures are made on areas of skin that have been previously abraded. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding.
- Short description of test conditions: Primary irritation to the skin is measured by a patch-test technique on the abraded and intact skin of the albino rabbit, clipped free of hair. A minimum of six subjects are used in abraded and intact skin tests. Introduce under a square patch, such as surgical gauze measuring 1 inch by 1 inch and two single layers thick, 0.5 milliliter (in the case of liquids) or 0.5 gram (in the case of solids and semisolids) of the test substance. Dissolve solids in an appropriate solvent and apply the solution as for liquids. The animals are immobilized with patches secured in place by adhesive tape. The entire trunk of the animal is then wrapped with an impervious material, such as rubberized cloth, for the 24-hour period of exposure. This material aids in maintaining the test patches in position and retards the evaporation of volatile substances.
- Parameters analysed / observed: After 24 hours of exposure, the patches are removed and the resulting reactions are evaluated on the basis of the following designated values:
Erythema and eschar formation:
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formations (injuries in depth) 4
Edema formation:
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well defined by definite raising) 2
Moderate edema (raised approximately 1 millimeter) 3
Severe edema (raised more than 1 millimeter and extending beyond the area of exposure) 4
The “value” recorded for each reading is the average value of the six or more animals subject to the test. Readings are again made at the end of a total of 72 hours (48 hours after the first reading). Evaluate the reactions of the abraded skin at 24 hours and 72 hours, as described in this paragraph. Add the values for erythema and eschar formation at 24 hours and at 72 hours for intact skin to the values on abraded skin at 24 hours and at 72 hours (four values). Similarly, add the values for edema formation at 24 hours and at 72 hours for intact and abraded skin (four values). The total of the eight values is divided by four to give the primary irritation score - GLP compliance:
- no
- Remarks:
- Study predates GLP
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mobil Chemical Company (Edison, NJ) Lot# 1086
- Expiration date of the lot/batch: not specified
- Purity test date: not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, humidity
- Stability under test conditions: stable for duration of test
- Solubility and stability of the test substance in the solvent/vehicle: not applicable - Species:
- rabbit
- Strain:
- not specified
- Remarks:
- Albino
- Details on test animals or test system and environmental conditions:
- Details on test animals and environmental conditions not provided.
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Remarks:
- Abraded and Non-Abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- Both abbraded and intact skin of the albino rabbit, clipped free of hair were used in this study. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding. The test material is held against the skin for 24 hours by a dermal patch covered with an occlusive dressing.
- Observation period:
- 24 and 72 hours post application
- Number of animals:
- Six
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch x 1 inch
- Type of wrap if used: impervious material such as rubberized cloth
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: 24 hours
OBSERVATION TIME POINTS (indicate if minutes, hours or days): 24 and 72 hours
SCORING SYSTEM:
- Method of calculation: After 24 hours of exposure, the patches are removed and the resulting reactions are evaluated on the basis of the following designated values:
Erythema and eschar formation:
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formations (injuries in depth) 4
Edema formation:
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well defined by definite raising) 2
Moderate edema (raised approximately 1 millimeter) 3
Severe edema (raised more than 1 millimeter and extending beyond the area of exposure) 4
The “value” recorded for each reading is the average value of the six or more animals subject to the test. Readings are again made at the end of a total of 72 hours (48 hours after the first reading). Evaluate the reactions of the abraded skin at 24 hours and 72 hours, as described in this paragraph. Add the values for erythema and eschar formation at 24 hours and at 72 hours for intact skin to the values on abraded skin at 24 hours and at 72 hours (four values). Similarly, add the values for edema formation at 24 hours and at 72 hours for intact and abraded skin (four values). The total of the eight values is divided by four to give the primary irritation score. A primary irritation index score of 5.0 or more was considered to indicate a primary dermal irritant. - Irritation parameter:
- primary dermal irritation index (PDII)
- Time point:
- other: 24h / 72h
- Score:
- 0.95
- Remarks on result:
- other: includes both abraded and non-abraded scores
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks:
- Effect persisted at 72 hours in 4 of 6 rabbits
- Remarks on result:
- other: 24 hour exposure, non-abraded
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0.7
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks:
- Study terminated at 72 hours
- Remarks on result:
- other: 24 hour exposure non-abraded
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: 1 animal had slight edema
- Remarks:
- 24 hour exposure, non-abraded
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- 24 hour exposure, non-abraded
- Other effects:
- Abraded skin Irritation scores (irritation parameter; basis; timepoint; value; max score; reversibility; remarks):
Erythema; mean; 24 hours; ca. 1.0; max score = 1.0; Effect persisted in 4 out of 6 rabbits at 72 hours; 24 hour exposure, abraded
Erythema; mean; 72 hours; ca. 0.7; max scoe = 1.0; not specified, study terminated at 72 hours; 24 hour exposure, abraded
Edema; mean; 24 hours; ca. 0.2; max score = 1.0; Fully reversible within 72 hours; 24 hour exposure, abraded
Edema; mean; 72 hours; ca. 0.0; max score = 0.0; 24 hour exposure, abraded - Interpretation of results:
- other: Not Irritating
- Conclusions:
- Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone did not produce evidence of primary skin irritation or corrosion in an in-vivo assay. While the exposure conditions do not align with current GHS criteria, the occlusive dressing and prolonged exposure time represent a worse case sceanrio. The low mean erythema and edema scores following such a prolonged exposure do not warrant classification of Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone as a dermal irritant.
- Executive summary:
The mean erythema and edema scores for Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone on unabraded skin were 1.0 and 0.2 respectively. These findings do not warrant classification of Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone as a dermal irritant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 April 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. Federal Hazardous Substances Act Consumer Product Safety Commission 16 CFR § 1500.42- Test for eye irritants.
- Version / remarks:
- Formerly U.S. Federal Hazardous Substances Act Food and Drug Commission 21 CFR § 191.12
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- - Principle of test: In the method of testing the ocular irritation of a substance referred to in § 1500.3(c)(4), six albino rabbits are used for each test substance.
- Short description of test conditions: Both eyes of each animal in the test group shall be examined before testing, and only those animals without eye defects or irritation shall be used. The test material is placed in one eye of each animal by gently pulling the lower lid away from the eyeball to form a cup into which the test substance is dropped. The lids are then gently held together for one second and the animal is released. The other eye, remaining untreated, serves as a control. For testing liquids, 0.1 milliliter is used. For solids or pastes, 100 milligrams of the test substance is used, except that for substances in flake, granule, powder, or other particulate form the amount that has a volume of 0.1 milliliter (after compacting as much as possible without crushing or altering the individual particles, such as by tapping the measuring container) shall be used whenever this volume weighs less than 100 milligrams. In such a case, the weight of the 0.1 milliliter test dose should be recorded. The eyes are not washed following instillation of test material except if noted.
- Parameters analysed / observed: The eyes are examined and the grade of ocular reaction is recorded at 24, 48, and 72 hours. - GLP compliance:
- no
- Remarks:
- Study predates GLP
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mobil Chemical Company (Edison, NJ) Lot# 1086
- Expiration date of the lot/batch: not specified
- Purity test date: not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
- Stability under test conditions: stable through duration of test
- Solubility and stability of the test substance in the solvent/vehicle: not applicable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not applicable - Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- mixed sex
- Details on test animals or tissues and environmental conditions:
- Details on test animals and environmental conditions not provided
TEST ANIMALS
- Source: not specified
- Age at study initiation: not specified
- Weight at study initiation: 1.8 -2.0 kg
- Housing: not specified
- Diet (e.g. ad libitum): not specified
- Water (e.g. ad libitum): not specified
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified
- Humidity (%): not specified
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): not specified - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of treatment / exposure:
- The test material is placed in one eye of each animal by gently pulling the lower lid away from the eyeball to form a cup into which the test substance is dropped. The lids are then gently held together for one second and the animal is released.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing
- Time after start of exposure:
SCORING SYSTEM: Scale of Weighted Scores for Grading the Severity of Ocular Lesion (Draize et al 1944)
Cornea
A. Opacity: Degree of density (area most dense taken for reading).
No ulceration or opacity 0
Scattered or diffuse areas of opacity (other than slight dulling of normal luster), details of iris clearly visible 1
Easily discernible translucent area, details of iris slightly obscured 2
Nacrous area, no details or iris visible, size of pupil barely discernible 3
Opaque cornea, iris not discernible through the opacity 4
B. Area of cornea involved
One quarter (or less), but not zero 1
Greater than one quarter, but less than one-half 2
Greater than one-half but less than three quarters 3
Greater than three quarters up to whole area 4
Score equals A x B x 5 Total maximum = 80
Iris
A. Values
Normal 0
Markedly deepened rugae, congestion, swelling moderate circumcorneal hyperemia, or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive) *1
No reaction to light, hemorrhage, gross destruction (any or all of these) *2
Score equals A x 5 Total possible maximum =10
Conjunctivae
A. Redness (refers to palpebral and bulbar conjunctivae, excluding cornea and iris).
Blood vessels normal 0
Some blood vessels definitely hyperemic (injected) 1
Diffuse, crimson color, individual vessels not easily discernible *2
Diffuse beefy red *3
B. Chemosis (refers to lids and/or nictitating membranes)
No swelling 0
Any swelling above normal (includes nictitating membranes) 1
Obvious swelling with partial eversion of lids *2
Swelling with lids about half closed *3
Swelling with lids more than half-closed *4
C. Discharge
Any amount different from normal (does not include small amount observed in inner canthus of normal rabbits) 1
Discharge with moistening of the lids and hairs just adjacent to the lids 2
Discharge with moistening of the lids and considerable area around the eye 3
Score equals (A + B + C) x 2 Total maximum = 20
TOOL USED TO ASSESS SCORE: not specified - Irritation parameter:
- cornea opacity score
- Remarks:
- non-weighted Draize
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Remarks:
- non-weighted Draize
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- non-weighted Draize
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Remarks:
- non-weighted Draize
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.16
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone did not produce evidence of eye irritation or corrosion in an in-vivo assay. These findings do not warrant classification of Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone as a Category 1 Serious Eye Damage or Category 2 Eye Irritant under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
- Executive summary:
The primary eye irritation potential of Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone was evaluated by application of test material to the eye of six albino rabbits. Mean non-weighted Draize scores for 24/48/72 hours were 0, 0.17, 0.22 and 0.16 for Cornela opacity, Iris, Conjuctival Redness, and Chemosis respectively. These findings do not warrant classification of Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone as an eye irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone did not produce evidence of skin irritation or corrosion in an in-vivo assay. These findings do not warrant classification of the substance as a Category 1 Skin Corrosive or Category 2 Skin Irritant under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Hydrazine Carboximidamide, 2-((2-hydroxyphenyl)methylene)-, reaction products with 2 undecanone did not produce evidence of serious eye damage or irritation in an in-vivo assay and does not warrant classification as Eye Damage Category 1 or Eye Irritant Category 2 under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.