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Diss Factsheets
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EC number: 904-797-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- The concentration and stability of the test item in the test preparations was verified by chemical analysis at 0, 24, 72 and 96 hours.
- Details on sampling:
- - Concentrations: Nominal concentrations of 10, 18, 32, 56 and 100 % v/v.
- Vehicle:
- no
- Test organisms (species):
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No additional post exposure period implemented in test design.
- Salinity:
- Not relevant for freshwater study
- Nominal and measured concentrations:
- The concentration and stability of the test item in the test preparations was verified by chemical analysis at 0, 24, 72 and 96 hours.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.7 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% confidence limits: 6.0 to 7.4 µg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 7.4 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: No lethal or sub-lethal effects were observed in any control fish.
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: There was a small amount of test item measured in the control sample at the 72 hours (fresh). This is considered to have been post sampling contamination as the 96 hour (old) sample had results of less that the limit of quantification. Therefore considered not to have impacted the outcome of the study. No sub lethal effects were observed in any control fish.
- Effect concentrations exceeding solubility of substance in test medium: Not applicable. - Sublethal observations / clinical signs:
Table 1: Cumulative mortality for the different concentration levels of the test compound:
Nominal
Concentration
(% v/v)
Cumulative Mortality (Initial Population = 7)
%
Mortality
1
Hour3
Hours6
Hours24 Hours
48 Hours
72 Hours
96 Hours
96
HoursControl
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
18
0
0
0
0
0
0
0
0
32
0
0
0
0
0
0
0
0
56
0
0
0
0
0
0
0
0
100
0
0
0
0
0
7
7
100
Table 2: Analytical result:
Concentration
(% v/v) Sat Sol
0 hours
24 hours old
72 hours fresh
96 hours old
Measured
Concentration(mg/L)
Measured
Concentration(mg/L)
Measured
Concentration (mg/l)Measured
Concentration(mg/L)
Control
<LOQ
<LOQ
0.00161
<LOQ
10
0.000972
0.000432
0.00223
0.000931
18
0.00186
0.000897
0.00316
0.00178
32
0.00355
0.00172
0.00614
0.00329
56
0.00628
0.00324
0.0101
0.00552
100
0.0123
0.00442
-
-
LOQ = 0.00030 mg/L
Table 3: Effect concentrations of the acute fish toxicity study.
(Hours)
LC50
(µg/L)95% Confidence Limits
(µg/L)NOEC
(µg/L)LOEC
(µg/L)96
6.7
6.0
-
7.4
6.0
7.4
- Validity criteria fulfilled:
- yes
- Conclusions:
- Acute toxicity of the test compound to freshwater fish was tested according to OECD Guideline 203.
Following results have been obtained after an exposure period of 96 hours: LC50 = 6.7 µg/L (95% confidence limits: 6.0 to 7.4 µg/L), NOEC = 6.0 µg/L, LOEC = 7.4 µg/L. - Executive summary:
Acute toxicity of the test compound to freshwater fish was tested according to OECD Guideline 203 and GLP. Nominal concentrations of 10, 18, 32, 56 and 100 % v/v have been investigated.
The concentration and stability of the test item in the test preparations was verified by chemical analysis at 0, 24, 72 and 96 hours.
At the highest nominal concentration level of 100 % v/v, measured test compound concentration was 12.3 µg/L (0 hours, i.e. at test begin) and 4.42 µg/L (after 24 hours), respectively. LOC was 0.30 µg/L.
Following results have been obtained after an exposure period of 96 hours: LC50 = 6.7 µg/L (95% confidence limits: 6.0 to 7.4 µg/L), NOEC = 6.0 µg/L, LOEC = 7.4 µg/L.
Time Point
(Hours)LC50
(µg/L)95% Confidence Limits
(µg/L)NOEC
(µg/L)LOEC
(µg/L)96
6.7
6.0
-
7.4
6.0
7.4
Reference
Description of key information
OECD 203, GLP, LC50 (96 h) = 0.0067 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.007 mg/L
Additional information
Acute toxicity of the compound reaction mass of m-terphenyl and o-terphenyl was investigatedaccording to OECD Guideline 203.
Following results have been obtained after an exposure period of 96 hours: LC50 = 6.7 µg/L (95% confidence limits: 6.0 to 7.4 µg/L), NOEC = 6.0 µg/L, LOEC = 7.4 µg/L.
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