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EC number: 600-337-9 | CAS number: 102691-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Two study reports (rated as Klimisch 1) on aquatic organisms are available covering two trophic levels: a primary producer (freshwater algae, represented by the model species Pseudokirchneriella subcapitata) and a primary consumer (aquatic invertebrates, represented by the model species Daphnia magna).
The freshwater algae P. subcapitata was exposed to 2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite for 72 hours in a GLP toxicity study (OECD 201) at 100, 32, 10, 3.2, and 1.0 mg/L. In this study a NOErC of 3.2 mg/L and an ErC50 of 20.4 mg/L were derived. The test concentrations were evaluated analytically by TOC. The relevant measured concentrations were ± 20 % of the nominal values.
D. magna was exposed for 48 hours to 2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite in a semi-static short-term GLP toxicity study (OECD 202) at 0.94, 2.20, 4.31, 9.63, 20.0, 33.2, 62.2 mg test item/L (calculated concentrations based on TOC measurements). In this study a NOEC of 0.96 mg/L and an EC50 of 22.8 mg/L were derived. The test concentrations were evaluated analytically by TOC.
In both studies the concentrations were analytically verified by TOC. The method was chosen because the test item hydrolyses very quickly, and the first hydrolysis product reacts further resulting in a continuous change in hydrolysis products. Therefore, it is not possible to focus on one single hydrolysis product for toxicity testing. In addition, no major and stable hydrolysis product could be found over the course of several days. To comprise all hydrolysis products TOC is the best suitable method for the present study.
Taking into account that 2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite is considered to be not readily biodegradable based on ThCO2 (Hammesfahr 2018) and the lowest EC50 value was determined to be > 10 mg/L and < 100 mg/L (72-h ErC50 = 20.4 mg/L), 2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite has to be classified as "Aquatic Chronic 3" (H412) following the provisions laid down in the CLP Regulation (Regulation (EC) No 1272/2008).
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