Registration Dossier
Registration Dossier
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EC number: 233-660-5 | CAS number: 10294-40-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remarks'
- Remarks:
- The EU RAR summarises a very large number of genotoxicity studies of varying quality and largely performed to non-standard designs. However the consistently positive responses mean that the studies taken as a whole are reliable. The RAR also covers studies discussed in earlier reviews by the UK HSE (1989) and the UK IOH (1997).
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR summarises the results of a large number of studies in vitro performed using chromium (VI) compounds, to various (and largely non-standard) protocols.
- GLP compliance:
- not specified
- Type of assay:
- other: Various in vitro methods are reviewed
Test material
- Reference substance name:
- Chromium
- EC Number:
- 231-157-5
- EC Name:
- Chromium
- Cas Number:
- 7440-47-3
- Molecular formula:
- Cr
- IUPAC Name:
- chromium
Constituent 1
Results and discussion
Test results
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
Any other information on results incl. tables
The results of a very large number of studies performed in vitro with the water-soluble hexavlent chromium compounds are largely positive.
The EU RAR therefore concludes that there is a very large body of evidence indicating that the Cr (VI) ion in solution is directly mutagenic in in vitro systems; this conclusion is relevant to all compounds in this group.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive weight of evidence approach
The weight of evidence in various test systems indicates that water soluble Cr (VI) compounds in this group are genotoxic in vitro. - Executive summary:
The EU RAR summarises the results of a number of in vitro studies of various designs and reliability performed over a number of years. The RAR itself also takes into account the findings of the earlier reviews of the toxicity of Cr (VI) compounds by the UK Health & Safety Executive (HSE, 1989) and the UK Institute of Health (IOH, 1997), which came to similar conclusions. It is concluded that water soluble Cr (VI) compounds are genotoxic in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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