Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-361-6 | CAS number: 939-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- Pre-existing in vivo study.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental studies were performed in a reliable research institute prior to establishment of international guidelines and GLP
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding toxicity Data: List IV
- Author:
- Smyth, Jr. H.F.
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4: 119-122
- Reference Type:
- review article or handbook
- Title:
- Safety assessment of alkyl benzoates as used in cosmetics
- Author:
- Becker LC, Bergfeld WF, Belsito DV, et al.
- Year:
- 2 012
- Bibliographic source:
- Int. J. Toxicol. 31:342S-72S
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.
- GLP compliance:
- no
- Remarks:
- Precedes establishment of GLP
Test material
- Reference substance name:
- Isopropyl benzoate
- EC Number:
- 213-361-6
- EC Name:
- Isopropyl benzoate
- Cas Number:
- 939-48-0
- Molecular formula:
- C10H12O2
- IUPAC Name:
- propan-2-yl benzoate
- Reference substance name:
- propan-2-yl benzoate
- IUPAC Name:
- propan-2-yl benzoate
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Amount / concentration applied:
- 5 microliters
- Observation period (in vivo):
- 24 h after instillation
- Number of animals or in vitro replicates:
- 5
- Details on study design:
- Five albino rabbits are selected. Prior to administering the test material, the animals are selected based on an absence of grossly visible staining in the eye by a 5% aqueous solution of fluorescein sodium, flushed with distilled water 20 seconds after application. After a two hour interval allowing the eye to return to normal, 0.005 ml of undiluted material is administered while the eye lid is retracted; about 1 minute later, the lids are released. Assessment of injury occurs 18-24 hours after administration, in strong diffuse daylight and then in an examination aided with fluorescein. The injury is then scored. A level of 5 (of 20) is representative of severe injury, corresponding to necrosis covering about 75% of cornea or a smaller area of more severe necrosis. Guided by the result and the table of injury grades, additional applications are made. The average injury score per animal is divided by 5 (number of animals) and assigned a grade. If dilution of a chemical is necessary, the preferred solvent is propylene glycol, and then water.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- non-standard scale
- Basis:
- mean
- Time point:
- other: 24 h after application
- Score:
- 1
- Max. score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- other: low irritation
- Irritant / corrosive response data:
- Using a non-standard scale to evaluate eye irritation, the score was 1 (of 20 maximum) at 24 h after application of IPB.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Using a non-standard scale to evaluate eye irritation in rabbits, the score was 1 (of 20 maximum) at 24 h after application of IPB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.