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Diss Factsheets
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EC number: 947-151-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Testing Methods for New Chemical Substances (Nov 21, 2003, No.1121002, Pharmaceutical and Food Safety Bureau, MHLW; Nov 13, 2003 No.2, Manufacturing Industries Bureau, METI; No.031121002, Environmental Policy Bureau, Ministry of the Environment)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- (2004)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidance Document No. 23 (Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures), 2000
- Deviations:
- not applicable
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: nominal 100 mg/L and control
- Sampling intervals: test start and end
- Sampling method:
test start: a sample was taken from the middle layer from the container for preparation;
test end: samples were taken from the middle layer of the test solution in the replicate vessels and combined
- Sample storage conditions before analysis: none - Vehicle:
- no
- Details on test solutions:
- The test material and dilution water were mixed to produce nominal 100 mg/L . The dispersions were stirred by magnetic stirrer for about 48 hours to prepare the test solution. After settling for 1 hour, an aliquot was taken from the middle layer of the dispersed suspension and used as the test solution.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Clone A
- Source: laboratory culture originating from a strain supplied by University of Sheffield, UK
- Age at study initiation: < 24h; not first brood
- Method of breeding: The parents to obtain young daphnids were bred in the same quality of water, water temperature and photoperiod as used in the test. Parents used for the test were of the same lot, 21 days old and their survival rate was 100%. Cultures were once a day with Chlorella vulgaris, to provide nominally 0.1 to 0.2 mg C/day per daphnia.
- Feeding during test: none
ACCLIMATION
not relevant since conditions were the same for maintenance and testing - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 28 mg/L (as CaCO3)
- Test temperature:
- 20.1 °C
- pH:
- 7.9
- Dissolved oxygen:
- 8.8-8.9 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- nominal: 100 mg/L
measured concentrations at test start and end: <0.022 mg/L (LOQ) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers, covered with lids; 100 mL fill volume
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: approx. 1 daphnid / 20 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water. Chemical characteristics are measured regularily
- Culture medium different from test medium: no
- Intervals of water quality measurement:
temperature, dissolved oxygen, pH and appearance of the test solutions: start and end of the exposure
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: artificial light (white fluorescent lamp), 16 hours light/8 hours darkness
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): immobility and symptoms were observed at 24 and 48 hours after the start of exposure.
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: nominal 100 mg/L (prepared as for the main test).
- Results used to determine the conditions for the definitive study: no effects were observed - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none
- Effect concentrations exceeding solubility of substance in test medium: none
The test solution was white and turbid with precipitations and floating substance during the whole exposure - Results with reference substance (positive control):
- The 48-hour EC50 was 0.30 mg/L (normal range in this laboratory: 0.13 to 0.35 mg/L)
- Validity criteria fulfilled:
- yes
- Remarks:
- In the control, no daphnids became immobilised, were trapped at the water surface or showed any signs of disease or stress. The oxygen concentration at the end of the test was ≥ 3 mg/L (> 60% air saturation) in control and test vessels.
Reference
Description of key information
48-h EC50 >100 mg/L (nominal) for Daphnia magna (OECD 202)
Key value for chemical safety assessment
Additional information
The results indicate that the test material is not toxic to daphnia up to the limits of its water solubility and a NOEC and thus a PNEC cannot be determined.
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