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EC number: 906-521-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 May - 20 Jun 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- Due to a malfunction of the cooling system on day 27 temperatures rose to a maximum of 45 °C on the last day of the test. This increase did not influence the overall test result.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of 2-hydroxyisopropyl 2-hydroxypropyl bicarbamate and 2-hydroxypropyl carbazate and propylene carbonate
- EC Number:
- 906-521-8
- Cas Number:
- 85391-60-2
- Molecular formula:
- C8H16N2O6
- IUPAC Name:
- Reaction mass of 2-hydroxyisopropyl 2-hydroxypropyl bicarbamate and 2-hydroxypropyl carbazate and propylene carbonate
- Test material form:
- liquid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from the aeration tank of the sewage treatment plant Odenthal, Germany (date of collection: 21 May 2002)
- Pretreatment: none
- Concentration of sludge: 30 mg/L ss - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Test temperature: 20 ± 1 °C
- pH: 7.5 (end of incubation); In one replicate the pH dropped to 5.9 due to malfunction of cooling apparatus
- pH adjusted: no
- Other: 25 mg test substance was weighed out on aluminium foil. This substance incl. aluminium foil was added to the test vessels.
TEST SYSTEM
- Culturing apparatus: Voith Sapromat (250 mL; continuously stirred)
- Number of culture flasks/concentration: 3
- Measuring equipment: BOD was continuously measured; NO2-N/NO2-N was analysed and the sum of both was determined by flow analysis (CFA and FIA) and spectrometric detection (EN ISO 13395)
- Test performed in closed vessels: yes
SAMPLING
- Sampling frequency: continuous analysis of BOD
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 3 bottles
- Abiotic sterile control: no
- Toxicity control: yes, 2 bottles
- Other: reference substance: yes, 3 bottles
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 28
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of three replicates
BOD5 / COD results
- Results with reference substance:
- The reference substance was degraded to 85% after 14 d and 90% after 28 d.
Any other information on results incl. tables
Table 1: Degradation of the test item, reference substance and toxicity
control during study period
Replicate |
Day |
4 |
6 |
8 |
12 |
14 |
18 |
20 |
22 |
26 |
28 |
|
|
Biodegradation of test item [%] |
|||||||||
1 |
|
8 |
13 |
16 |
19 |
21 |
25 |
26 |
29 |
32 |
25 |
2 |
6 |
12 |
14 |
18 |
20 |
23 |
24 |
25 |
27 |
21 |
|
3 |
8 |
13 |
16 |
19 |
21 |
25 |
26 |
27 |
30 |
37 |
|
Mean |
7 |
13 |
15 |
19 |
21 |
24 |
25 |
27 |
30 |
28 |
|
|
|
Biodegradation of reference item [%] |
|||||||||
1 |
|
61 |
71 |
77 |
82 |
84 |
88 |
89 |
89 |
91 |
89 |
2 |
62 |
72 |
79 |
85 |
88 |
91 |
92 |
94 |
95 |
94 |
|
3 |
62 |
71 |
77 |
82 |
84 |
87 |
88 |
89 |
91 |
86 |
|
Mean |
62 |
71 |
78 |
83 |
85 |
89 |
90 |
91 |
92 |
90 |
|
|
|
Biodegradation of toxicity control [%] |
|||||||||
1 |
|
41 |
48 |
54 |
59 |
60 |
63 |
64 |
65 |
66 |
65 |
2 |
41 |
49 |
54 |
60 |
62 |
64 |
65 |
66 |
68 |
67 |
|
Mean |
41 |
49 |
54 |
60 |
61 |
64 |
65 |
66 |
67 |
66 |
The BOD values on day 28 were corrected for the oxygen consumed by nitrification.
Table 2: Oxygen uptake by nitrification
|
Time |
NO3-N [mg/L] |
Oxygen uptake [mg/L] |
NO2-N [mg/L] |
Oxygen uptake [mg/L] |
Test substance |
0 h |
< 1.00 |
4.57 |
< 0.10 |
0.34 |
Test substance |
28 d |
1.37 |
6.26 |
< 0.10 |
0.34 |
Oxygen uptake |
28 d |
- |
1.69 |
- |
0.00 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
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