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Diss Factsheets
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EC number: 206-126-4 | CAS number: 302-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Remarks:
- Danish (Q)SAR Database, http://qsar.food.dtu.dk
- Justification for type of information:
- The literature reference of Yalkowsky 1992 is mentioned in the Danish QSAR database.
The database is developed by the National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency. - Principles of method if other than guideline:
- not specified in the handbook
- Type of method:
- other: not specified in the handbook
- Water solubility:
- 166 000 mg/L
- Remarks on result:
- other: Temp not specified
- Conclusions:
- Water solubility Experimental: 166000 mg/L
DL-alanine is very water soluble
Reference
Description of key information
According to different values stated in two handbooks water solubility of D,L-alanin is in mean at 25 °C 157 g/L. The different stated values are all quite similar (please refer to 'Additional information'). The mean experimental value is supported by a theoretically derived water solubility.
Key value for chemical safety assessment
- Water solubility:
- 157 g/L
- at the temperature of:
- 25 °C
Additional information
CRC, Yalkowsky:
According to the CRC Handbook of aqueous solubility data, the water solubility of DL-Alanine is at 25 °C stated with different values (based on the specific source). In conclusion the arithmetic mean was chosen to state a definitive value:
(147.8 g/L + 142.2 g/L + 142.4 g/L + 143.2 g/L + 169.3 g/L + 136.3 g/L) / 5 = 146.9 g/L
CRC, Lange:
According to the CRC Lange's Handbook of chemistry , the water solubility of DL-Alanine is 167g/L at 25 °C.
Banerjee (1996), UNIFAC-estimated
The water solubility was calculated using an UNIFAC-based algorithm. A solubility of 1.5 - 3.8 M (133.7 - 338.6 g/L) was calculated for D,L-Alanine in the temperature range of 10 - 80 °C.
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