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EC number: 221-178-8 | CAS number: 3025-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyl (2E,4Z)-2,4-decadienoate
- EC Number:
- 221-178-8
- EC Name:
- Ethyl (2E,4Z)-2,4-decadienoate
- Cas Number:
- 3025-30-7
- Molecular formula:
- C12H20O2
- IUPAC Name:
- ethyl deca-2,4-dienoate
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3426-04699
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: less than 10 degrees C under N2 atmosphere
Test animals
- Species:
- rabbit
- Strain:
- other: little white Russian, Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomae GmbH
- Weight at study initiation: 2.1-2.6 kg
- Housing: individually in stainless steel cages
- Diet (e.g. ad libitum): K4 Alleindiat fur Kaninchen, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 14 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 1 degree C
- Humidity (%): 60 +/- 5%
- Air changes (per hr): 15 x per hour
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
IN-LIFE DATES: From: September 17, 1986 To: October 2, 1986
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 cc
- Concentration (if solution): 98.8% - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: Gauze covered by a polyethylene film, which was then covered by a plastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 hrs
OBSERVATION TIME POINTS
(indicate if minutes, hours or days)
1, 24, 48, 72 hrs
6, 9, 12, 14 days
SCORING SYSTEM:
- Method of calculation: Edema and eschar were evaluated on a scale of 0-4 (0 no erythema, 4 severe erythema and eschar). Edema was also evaluated on a scale of 0-4 (0 no edema, 4 severe edema).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hrs
- Score:
- 4.25
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritant / corrosive response data:
- All animals exhibited redness and swelling at the first oberservation (1 hr) which per persisted through Day 6. Scabbing and cracking was still seen in all animals at Day 14.
Any other information on results incl. tables
|
Animal 19781 |
Animal 19801 |
Animal 30003 |
Redness – 1 hour |
2 |
1 |
2 |
Swelling -1 hour |
1 |
1 |
2 |
Redness – 24 hours |
2 |
2 |
2 |
Swelling -24 hours |
2 |
1 |
2 |
Redness – 48 hours |
3 (slight yellowing) |
3 |
3 |
Swelling -48 hours |
3 |
2 |
2 |
Redness – 72 hours |
3 (slight yellowing) |
3 |
3 |
Swelling - 72 hours |
2 |
2 |
2 |
Redness – 6 days |
3 (scabbing, cracking, yellow-brown) |
3 (scabbing, cracking) |
3 (scabbing, cracking, yellow-brown) |
Swelling – 6 days |
2 |
1 |
2 |
Redness – 9 days |
Scabbing, cracking |
Scabbing, cracking |
Scabbing, cracking |
Swelling – 9 days |
-- |
-- |
-- |
Redness – 12 days |
Scabbing, cracking |
Scabbing, cracking |
Scabbing, cracking |
Swelling – 12 days |
-- |
-- |
-- |
Redness – 14 days |
Scabbing, cracking |
Scabbing, cracking |
Scabbing, cracking |
Swelling – 14 days |
-- |
-- |
-- |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test substance is moderately irritating to skin.
- Executive summary:
The skin irritation potential of the test substance was determined in an OECD Guideline 404 study. 3 male rabbits were exposed to 0.5 cc of test substance for 4 hrs. The test substance was then removed, and observations made at 1, 24, 48, and 72 hrs after removal, and also at 6, 9, 12, and 14 days after removal. All animals showed evidence of irritation that was not fully resolved by Day 14. The test substance is moderately irritating to skin.
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