Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-590-2 | CAS number: 123-00-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-10-30 to 1993-01-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-morpholinopropylamine
- EC Number:
- 204-590-2
- EC Name:
- 3-morpholinopropylamine
- Cas Number:
- 123-00-2
- Molecular formula:
- C7H16N2O
- IUPAC Name:
- 3-morpholin-4-ylpropan-1-amine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: no data
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: no data
- Solubility and stability of the test substance in the solvent/vehicle: not provided
OTHER SPECIFICS:
- Specific gravity: 0.9888 g/mL
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Products, Denver PA
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: 2.430 - 3.131 kilograms
- Housing: Rabbits were housed individually in cages sized in accordance with the "Guide for the care and Use of Laboratory Animals" of the Institute of Laboratory Animal Resources, National Research Council.
- Diet (e.g. ad libitum): Purina Lab Rabbit Chow H.F.®, checked daily and added or replaced as needed according to standard Operating Procedure PH-113.
- Water (e.g. ad libitum): Fresh tap water, ad libitum.
- Acclimation period: Minimum of five (5) days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°c ± 3°C
- Humidity (%): 30 to 70%.
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- % coverage: no data
- Type of wrap if used: The test article was applied directly onto the exposed intact skin of the animals taking care to spread the substance evenly over the entire area. A square gauze patch was placed on the animals to cover the dosed area. The animals were wrapped with a rubber dam and an elastic bandage to retard evaporation.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Following the twenty-four hour period of exposure, the wrappings were removed and the skin sites were wiped with water and gauze to remove any residual test article.
- Time after start of exposure: The test article was applied once and remains in contact with the skin site for twenty-four hours.
- Duration of exposure:
- Administered once and remained in contact with the skin site for twenty-four hours.
- Doses:
- 1000, 2000 and 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were recorded daily through Day 14. Body weights were recorded at initiation and on Days 7 and 14 or when found dead.
- Necropsy of survivors performed: yes, on Day 14 - Statistics:
- By the method of Litchfield and Wilcoxon via the Innovative Programming Associates, LABCAT Module Version 4.24.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 219.7 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 396.1 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 297.9 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died at the 1000 mg/kg dose level.
Three of ten animals died at the 2000 mg/kg dose level and eight of ten animals died at 3000 mg/kg. - Clinical signs:
- Clinical signs observed included decreased activity, abnormal gait, abnormal stance, decreased muscle tone, dyspnea and prostration.
Necrosis and/or sloughing of the skin at the application site was also observed during the study. - Body weight:
- There was an apparent decrease in mean body weight of both males and females during the course of the study.
- Gross pathology:
- Necropsy of the animals that died on study revealed distended stomach and intestines, discolored kidneys, lungs and liver and necrosis of the skin at the application site. At terminal necropsy, necrosis of the skin at the application site was observed in all animals. No other visible lesions were observed in any animal at terminal necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the observations made in the Acute Exposure Dermal Toxicity study in rabbits, the definitive acute dermal LD50 in males, females and combined sexes was determined to be 2219.7, 2396.1 and 2297.9 mg/kg respectively. Based on these LD50 values and the criteria of the CLP Regulation, the test item should not be classified for acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.