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EC number: 264-776-4 | CAS number: 64325-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Two study reports (rated as Klimisch 1 and 2) on aquatic organisms are available covering two trophic levels: a primary producer (freshwater algae, represented by the model species Pseudokirchneriella subcapitata) and a primary consumer (aquatic invertebrates, represented by the model species Daphnia magna).
P. subcapitata was exposed for 72 hours to N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine in a growth inhibition test (according to OECD guideline 201 and under GLP) at a limit concentration of 220 µg/L (measured, limit of water solubility, loading 100 mg/L nominal). The test concentration was determined analytically by HPLC-UV. No effect on P. subcapitata was observed. Therefore, N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine is not toxic to P. subcapitata up to the limit of water solubility.
The aquatic invertebrate D. magna was exposed to N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine for 48 hours in a GLP toxicity study (OECD 202) at nominal concentrations of 25, 50, 100, 200, and 400 mg/L. As the substance is poorly soluble (water solubility of 140 µg/L in distilled water, see section 4.8 in the present dossier) only low concentrations were achieved after shaking the test solution for 48 h. Since a LOQ for the analytical method of less than 1.0 mg/L could not be achieved, none of the test concentrations could be verified analytically with sufficient reliability. Nevertheless, test substance concentrations could be measured in the range above the LOD (= 0.05 mg/L) but below the LOQ in the two highest treatment levels (200 and 400 mg/L nominal). Based on immobilization rates and measured concentrations, an EC50 (48 h) of 170 µg/L could be determined.
Since N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine is not readily biodegradable, and the lowest effect value was < 1 mg/L (EC50 = 170 µg/L, LOEC ≥ 50 µg/L), N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine has to be classified as "Aquatic Acute 1" (H400) and “Aquatic Chronic 1 (H410)” following the provisions laid down in the CLP Regulation (Regulation (EC) No 1272/2008).
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