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Diss Factsheets
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EC number: 275-062-7 | CAS number: 70955-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- (no data on starting date) 30-AUG 1976 (date of report)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted before GLP principles (1976). However, study performed according to basic scientific principles acceptable for assessment although some information is missing on test conditions and on tes substance composition.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: performed according to standard method
- Deviations:
- not applicable
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Santal synthétique
- Analytical purity: not specified
See confidential details on test material for more information
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data available
- Age at study initiation: no data available
- Weight at study initiation: no data available
- Housing: no data available
- Diet (e.g. ad libitum): no data available
- Water (e.g. ad libitum): no data available
- Acclimation period: no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data available
- Humidity (%): no data available
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): no data available
IN-LIFE DATES: From: To: no data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact skin and abraded skin
- Vehicle:
- other: vaseline oil
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration: 100% (as such) and 30% (diluted product in vaseline oil)
VEHICLE
Vaseline oil. No other information available.
NEGATIVE CONTROL
No data available
POSITIVE CONTROL
No data available - Duration of treatment / exposure:
- no data available
- Observation period:
- 3 days
- Number of animals:
- 6 for each concentration
- Details on study design:
- TEST SITE
- Area of exposure: no data available. The product has been applied on the intact and abraded skin.
- % coverage: no data available
- Type of wrap if used: no data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data available
- Time after start of exposure: no data available
OBSERVATION TIME POINTS
24 and 72 hours
SCORING SYSTEM:
- Method of calculation: no data available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Reversibility:
- not specified
- Remarks on result:
- other: Intact skin / product as such (concentration: 100%)
- Remarks:
- 48h: not determined
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: intact skin / product as such (concentration: 100%)
- Remarks:
- 48h: not determined
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.25
- Reversibility:
- not specified
- Remarks on result:
- other: abraded skin / product as such (concentration: 100%)
- Remarks:
- 48h not determined
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Reversibility:
- fully reversible
- Remarks on result:
- other: abraded skin / product as such (concentration: 100%)
- Remarks:
- 48h not determined
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.29
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- other: 48h not determined
- Irritant / corrosive response data:
- Based on this score, the substance is slightly irritating to rabbit's skin.
No detail is given to the concentration of 30%, since no signs of irritation were noted.
Any other information on results incl. tables
Table 1: local skin tolerance in rabbits - 100% concentration (product as such)
Observation after : |
Rabbit N° |
Intact skin |
Abraded skin |
||
Erythema |
Edema |
Erythema |
Edema |
||
24 hours |
1 2 3 4 5 6 |
1 1 0 1 2 1 |
0 0 0 0 0 0 |
2 2 2 2 2 2 |
2 1 1 1 2 1 |
72 hours |
1 2 3 4 5 6 |
0 1 0 0 1 0 |
0 0 0 0 0 0 |
1 1 0 0 1 0 |
0 0 0 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the Un GHS and CLP criteria, the substance is not classified for the skin irritation.
- Executive summary:
Rhodiantal IBCH (100% (as such) and 30% (diluted product in vaseline oil) has been applied to the intact and abraded skin of six rabbits.
Period of observation: 24 and 72 hours. No more information is available.
Results: For the concentration of 100%, the mean scores (24 and 72h) were 0.66 for erythema and 0 for edema on the intact skin . Based on this score the substance is slightly irritating to rabbit’s skin.
According to the UN GHS and CLP criteria, the substance is not classified for the skin irritation.
For the concentration 30%, no signs of irritation were noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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