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Diss Factsheets
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EC number: 701-246-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Report of apparently well conducted human volunteer trial with detail of volunteer panel and reactions to treatment. Test material said to be directly comparable to pinene oliogomers (and reported characteristics support this). Study findings are supported by a separate (incompletely reported) human repeat-insult patch test of the same test substance in which 50 male volunteers apparently showed no skin irritation or sensitisation reactions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Closed patch applied to skin of human volunteers for 24h: after recording of irritation, challenge by repeat patching 10-14 days later.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Foxlene Type M
- IUPAC Name:
- Foxlene Type M
- Reference substance name:
- Oligomerisation products of beta-pinene
- EC Number:
- 701-246-8
- Molecular formula:
- Variable (dimer = C20-H34)
- IUPAC Name:
- Oligomerisation products of beta-pinene
- Details on test material:
- - sample number 1158
- substance produced by reaction directly equivalent to that now used for manufacture of pinene oligomers and identified as terpene polymer. Reported MW corresponds to the number-average MW of pinene oligomers.
Constituent 1
Constituent 2
Method
- Ethical approval:
- not specified
- Subjects:
- 42 adult males, 18-57 years old, 11 with declared allergies. 15 adult females, 18-57 years old, 4 with declared allergies.
- Controls:
- None
- Route of administration:
- dermal
- Details on study design:
- The flexor surface of one forearm was swabbed with acetone/ethyl acetate to promote localised defatting. To this area was applied a blotting paper disc (white, 1 cm diameter x 0.5 mm thick) which had been dipped into undiluted test substance. The test site was then covered with an Elastopatch adhesive strip for 24h. After removal, local reactions were observed immediately and then periodically between 10 and 14 days after first patch removal the patching procedure was repeated using the same general area of skin.
Results and discussion
- Results of examinations:
- No skin reactions observed after 1st and 2nd patch removal in any test subject.
Any other information on results incl. tables
No skin reactions indicative of primary irritation or contact sensitisation were observed in human volunteers.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, no evidence of human contact sensitisation was obtained.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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