Registration Dossier
Registration Dossier
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EC number: 206-687-5 | CAS number: 367-25-9
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,4-difluoroaniline
- EC Number:
- 206-687-5
- EC Name:
- 2,4-difluoroaniline
- Cas Number:
- 367-25-9
- Molecular formula:
- C6H5F2N
- IUPAC Name:
- 2,4-difluoroaniline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pimephales promelas
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Nominal and measured concentrations:
- Nominal: 6.25, 12.5, 25.0, 50.0, and 100 mg/L
Measured: 6.14, 12.2, 25.5, 51.0 and 103 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 40 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- 95% confidence interval: 26.0 - 71.2 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 6.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Lethal effects were observed from the concentration of nominal 12.5 mg test item/L up to the highest concentration of 100 mg test item/L.
The effect value for the short-term toxicity to fish is LC50 (96 h) = 40.0 mg/L (nominal) and LC0 (96h) = 6.25 mg/L (nominal).
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