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EC number: 270-365-0 | CAS number: 68425-65-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27-Feb-17 to 26-Apr-17.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The objective of the study was to estimate the solubility in water and to assess fast hydrolysis
at 3 pHs (i.e. acidic, neutral and basic: about pH 4 to 9) of the test item. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oxo(propan-2-olato)aluminium
- EC Number:
- 270-365-0
- EC Name:
- Oxo(propan-2-olato)aluminium
- Cas Number:
- 68425-65-0
- Molecular formula:
- C3 H7 Al O2
- IUPAC Name:
- oxo(propan-2-olato)aluminium
- Test material form:
- solid: particulate/powder
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Hydrolysis tests were performed at 20 ± 0.5°C until at least 80 % or more of the test item
were hydrolyzed. Hydrolysis was examined in demineralized water and in aqueous buffer
solutions at pH 4, 7 and 9. Aliquots of the hydrolysis system were collected at several time
points and analysed immediately by HS-GC-MS to follow the formation of the expected
hydrolysis product 2-propanol. Analysis of the intact test item complex was considered not
possible. - Buffers:
- Aqueous buffer solutions were prepared as follows:
pH 4 (0.05 M) Citrate Buffer: 23 g of potassium dihydrogen citrate was dissolved in 1 L of water. An aliquot of 0.50 L was mixed with 0.09 L of 0.1 M NaOH and filled up with water to 1 L to give a pH of 4.
pH 7 (0.05 M) Phosphate Buffer: 13.6 g of potassium dihydrogen phosphate was dissolved in 1 L of water. An aliquot of 0.50 L was mixed with 0.296 L of 0.1 M NaOH and filled up with water to 1 L to give a pH of 7.
pH 9 (0.05 M) Borate Buffer: 19 g of sodium tetraborate decahydrate were dissolved in 1 L of water. An aliquot of 0.85 L was mixed with 0.15 L of 0.1 M HCl (prepared from 10 M HCl, Merck,
32 %) to give a pH of 9. - Details on test conditions:
- Generally 25 μL of the spike solution (10 mg/mL XP 473) were diluted in a final volume of
250 mL of buffer solution or demineralized water in glass bottles and shaken vigorously or in
other volumes by considering the volume ratio. The resulting concentration of the substance was
1.0 mg/L (approx. 10 -5 mol/L).
Two replicate test solutions were prepared for water and each buffer solution.
Aliquots of the test solutions (2.0 mL) were transferred into individual autosampler vials.
These aliquots were measured with HS-GC-MS without delay.
Duration of testopen allclose all
- Duration:
- 49 min
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 1 mg/L
- Remarks:
- Substance dosed as 10 mg/mL solution in DMSO: e.g 0.05 mL (0.5 mg) added to 0.5 L of buffer,
resulting in an initial concentration of 1 mg substance / L of buffer. Ca 8% remaining after 2 min.
- Duration:
- 76 min
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 1 mg/L
- Remarks:
- Substance dosed as 10 mg/mL solution in DMSO: e.g 0.025 mL (0.25 mg) added to 0.25 L of buffer
sample, resulting in an initial concentration of 1 mg XP473 / L of buffer. Ca. 9% remaining after 4 min.
- Duration:
- 49 min
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 1 mg/L
- Remarks:
- XP473 dosed as 10 mg/mL solution in DMSO: e.g 0.05 mL (0.5 mg) added to 0.5 L of buffer sample,
resulting in an initial concentration of 1 mg XP473 / L of water/buffer. Ca. 5% remaining after 2 min.
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Isopropanol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 200-661-7]
- CAS number:
- 67-63-0
- Molecular formula:
- C3 H8 O
- Molecular weight:
- 60.1
Dissipation DT50 of parent compoundopen allclose all
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- < 2 min
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- < 2 min
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- < 2 min
- Type:
- not specified
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Mean accuracies were in the acceptable range from 105 % to 103 % of the expected nominal values.
- Conclusions:
- Within the first three minutes more than 80 % of the amount of test item dosed was already
hydrolysed to form 2-propanol. The half-life of the test item is estimated to be shorter than 2
minutes in demineralised water and in the pH 4, pH 7 and pH 9 aqueous buffer solutions.
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