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EC number: 247-956-7 | CAS number: 26748-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-04-04 to 1978-07-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- 1 hour exposure instead of 4 hours
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methyl-1-phenylethyl peroxyneodecanoate
- EC Number:
- 247-956-7
- EC Name:
- 1-methyl-1-phenylethyl peroxyneodecanoate
- Cas Number:
- 26748-47-0
- Molecular formula:
- C19H30O3
- IUPAC Name:
- 1-methyl-1-phenylethyl 2-ethyl-2,5-dimethylhexaneperoxoate
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: SN-1-4462-71X
- Chemical name: cumyl peroxyneodecanoate
- Purity: 75.5% (0.19% Hydro, 896 ppm Cl)
- Appearance: pale yellow liquid
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS & ENVIRONMENTAL CONDITIONS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 235-242 g (male rats), 200-214 g (female rats)
- Fasting period before study: no data
- Housing: The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post-exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DHEW No. (N.I.H. 74-23) 1974". During exposure, the rats were caged individually in compartmented wire-mesh exposure cages. The cages were placed in a 160-liter cubical, stainless steel and glass chamber. A constant chamber airflow was maintained by means of a rotary centrifugal air pump located at the exhaust side of the chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute® filter before being discharged outside of the laboratory.
- Diet (e.g. ad libitum): Purina Laboratory chow, ad libitum (except in the exposure chamber)
- Water (e.g. ad libitum): ad libitum (except in the exposure chamber)
- Acclimation period: 1 week
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapors of the compound were generated by metering the liquid at the rate of 0.494 mL/min with a Harvard Infusion pump into a positive pressure atomizer located near the chamber air inlet at the top of the exposure chamber. An air pressure of 10 psig, with an air-flow rate of 8 L/min, was applied to the atomizer which aerosolized the liquid for rapid vaporization. The vapors and aerosols emerging from the atomizer were diluted by the incoming chamber air at the rate of 14 L/min to the desired concentration. The "metered" concentration of the compound (20.4 mg/L) in the chamber atmosphere was calculated from the ratio of the rate of liquid dissemination (449.5 mg/min*) to the rate of total chamber airflow (22 L/min). The total chamber airflow represents the volume of air ejected from the atomizer plus the volume of make-up air passing through the chamber per unit time.
*The specific gravity of the liquid was gravimetrically determined to be 0.91 - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 20.4 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Observations for toxic signs and mortility were made during and immediately following the 1 hour exposure period and twice daily thereafter for 14 days.
- Frequency of weighing: Individual body weights were recorded prior to the 1 hour exposure and periodically thereafter.
- Necropsy of survivors performed: yes - Statistics:
- no data
Results and discussion
- Preliminary study:
- n.a.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 20.4 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- None of the rats died in the experiment.
- Clinical signs:
- other: The immediate response of the rats to the experimental atmosphere was an increase of activity in preening. After several minutes of exposure, this activity decreased. After 20 minutes of exposure 50% of the rats exhibited slight dyspnea. At 30 minutes, al
- Body weight:
- A slight body weight loss was observed in the rats for 1-5 day post-exposure. By the end of the 14-day post-exposure, the body weights of all the rats exceeded those of the pre-exposure values. See Table 1 in box 'Any other information on results incl. tables'.
- Gross pathology:
- Gross pathological examination of the rats which were sacrificed at the end of the experimental period revealed gray patches on the lungs of 1 male rat and no compound related pathologic changes in the remaining 9 rats.
Any other information on results incl. tables
Table 1: Individual Body Weights
Individual body weights (in grams) | |||||||
Pre-exposure | Post-exposure (Days) | ||||||
0 | 1 | 3 | 5 | 7 | 14 | ||
Rat no. | Sex | ||||||
1 | M | 235 | 220 | 232 | 262 | 286 | 346 |
2 | M | 240 | 225 | 240 | 260 | 285 | 328 |
3 | M | 238 | 224 | 236 | 258 | 276 | 320 |
4 | M | 235 | 221 | 238 | 258 | 271 | 300 |
5 | M | 242 | 224 | 236 | 255 | 272 | 295 |
6 | F | 200 | 192 | 200 | 211 | 218 | 236 |
7 | F | 200 | 202 | 205 | 212 | 226 | 228 |
8 | F | 210 | 192 | 222 | 211 | 224 | 240 |
9 | F | 214 | 200 | 210 | 220 | 229 | 250 |
10 | F | 210 | 199 | 200 | 207 | 224 | 232 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation study, Charles River CD rats were inhaled via whole-body exposure to 20.4 mg/L for 1 hour. No mortality occurred during the 14-day observation period. Based on the results, the LC50 is considered to be greater than 20.4 mg/L.
- Executive summary:
In an acute inhalation toxicity study conducted similar to OECD 403, groups of Charles River CD rats (5/sex) were exposed by inhalation route to LUPERSOL 188M75 containing 75.5% cumyl peroxyneodecanoate (0.19% Hydro; 896 ppm Cl-) for 1 hour to whole body at a concentration of 20.4 mg/L. Animals then were observed for 14 days. No mortality occurred. During exposure, animals showed an increase of activity in preen in and all rats exhibited slight dyspnea and some rats exhibited salivation. One rat exhibited eye squint on day 1 post-exposure. A slight body weight loss was observed in the rats for day 1 to 5 post-exposure. In one male rat, grey patches on the lungs were observed. Based on the results, the LC50 is greater than 20.4 mg/L.
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