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Diss Factsheets
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EC number: 426-540-0 | CAS number: 2973-59-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-01-06 to 1998-03-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The purity of the test substance was 91.3 % (according to OECD 111 the purity of the test substance should be at least 95%).
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- - Lighting conditions during the incubation period not reported. - Purity of test substance: 91.3 %
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate issued by the Swiss GLP monitoring authorities.
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 00265786
- Expiration date of the lot/batch: 1998-07-01 (retest date)
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature at about 20°C - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: before the start of incubation, at 2.4 and 120 hours
- Sampling method: no data
- Sampling methods for the volatile compounds, if any: no data
- Sampling intervals/times for pH measurements: not performed
- Sampling intervals/times for sterility check: not performed
- Sample storage conditions before analysis: no data
- Other observation, if any (e.g.: precipitation, color change etc.): no data - Buffers:
- - pH: 4, 7, 9
- Type and final molarity of buffer: biphthalate (pH 4.0); phosphate (pH 7.0); borate/potassium chloride/NaOH (pH 9.0), the final molarity not provided
- Composition of buffer: The buffer solutions contained 2% dimethylformamide (DMF) as a solubilizing agent. The buffer solutions were sterilized for 25 minutes in an autoclave prior to first use. Nitrogen was passed through the buffer solutions for 2 minutes except when freshly sterilized. - Estimation method (if used):
- not applicable
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: The hydrolysis was carried out in glass Erlenmeyer flasks which were stoppered or sealed with an inert material (e.g., PTFE).
- Sterilisation method: All glassware was inert in the applied pH range applied and was rinsed with sterile buffer. The buffer solutions were sterilized for 25 minutes in an autoclave prior to first use.
- Lighting: no data
- Measures taken to avoid photolytic effects: no data
- Measures to exclude oxygen: Nitrogen was passed through the buffer solutions for 2 minutes except when freshly sterilized.
- Details on test procedure for unstable compounds: not applicable
- Details of traps for volatile, if any: not applicable
- If no traps were used, is the test system closed/open: The hydrolysis was carried out in flasks which were stoppered or sealed with an inert material (e.g. PTFE).
- Is there any indication of the test material adsorbing to the walls of the test apparatus?: no data
TEST MEDIUM
- Volume used/treatment: 50 mL
- Kind and purity of water: Milli-Q
- Preparation of test medium: Appropriate amounts of the test substance were dissolved in 100 mL buffer solution (pH 4.0 - ph 7.0 and pH9) containing 2 %
DMF as solubilizer. This mixture was ultrasonified for 1 minute and was passed through a 0.45 µm polyamide filter. To obtain a test solution of not more than half the water solubility, the solution was diluted 1:1 with the respective buffer. Two aliquots of this test solution of approximately 50 mL each were transferred into 50 mL Erlenmeyer flasks in order to perform a duplicate test.
- Renewal of test solution: no
- Identity and concentration of co-solvent: DMF (2%)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Dissolved oxygen: no data - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 89.1 - <= 89.8 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 80 - <= 80.7 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 95 - <= 95.1 mg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- no data
- Preliminary study:
- The results at pH 4.0, 7.0 and pH 9.0 showed no significant degradation of T002019 at 50 °C. According to the guideline, no further tests were required.
- Test performance:
- There were no circumstances that may have affected the quality or integrity of the study.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- - Formation and decline of each transformation product during test: no data
- Pathways for transformation: no data
- Other: no data - % Recovery:
- > 90
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The hydrolysis determination of T002019 at pH 4.0, 7.0 and 9.0 (OECD 111) showed no significant degradation of the test substance at 50°C. The degradation of the test substance was less than 10 % after 5 days. It can be concluded, that the estimated half-life time is higher than one year under representative environmental conditions (25°C). Therefore, the test substance was considered to be hydrolytically stable, and no further testing was necessary. The results of the test can be considered reliable with restriction: the fulfilling of the validity criteria were not specified. Moreover a purity of 91.3 % was reported for the test substance (according to OECD 111 the purity of the test substance should be at least 95%).
Reference
Description of key information
One study (Tognucci, 1998) was performed according to OECD guideline 111 and regarded as a key study (Klimisch score of 2). A half-life time of > 1 year at 25 °C and pH 7, was determined for T002019.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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