cis-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-03-13 to 2017-03-13

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)

Deviations:

no

GLP compliance:

yes

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Analytical purity: impurities: R036844 3.30%, unknown <0.10%
- Source and lot/batch No.of test material:
* batch: I15DB1648
* test item: 207556/A
- Expiration date of the lot/batch: 2020-04-19 (retest date)
- Purity test date: 2015-05-27 (certificate of analysis release date)

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: solubility in water: <0.05 g/L

Radiolabelling:

no

Analytical monitoring:

no

Details on test conditions:

Since the water solubility of the test item was 0.012 mg/L, no analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Positive controls:

no

Negative controls:

no

Preliminary study:

not carried out

Transformation products:

not measured

Remarks on result:

not determinable because of methodological limitations

Details on results:

According to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. The water solubility of the test item is 0.012 mg/L. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Conclusions:

According to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. The water solubility of the test item is 0.012 mg/L. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Description of key information

Based on the guideline study (Ciric 2017) it is concluded that the water solubility of the test item is 0.012 mg/L, since according to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.