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EC number: 812-962-6 | CAS number: 34354-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-10-23 to 2017-10-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 157.1
- Version / remarks:
- CIPAC Handbook Volume F, “Physico chemical Methods for Technical and Formulated Pesticides”, W. Dobrat and A. Martijn (1995)
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- (Off)-white, crystalline powder
- Key result
- Water solubility:
- < 10 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 10 min
- Temp.:
- 20 °C
- Remarks on result:
- other: for this preliminary test pH was not measured
- Details on results:
- The water solubility of the test item was determined at approx. 20 °C to be < 10 mg/L.
For details, please see section “any other information on results incl. tables”. - Conclusions:
- The water solubility of the test item at approx. 20 °C was < 10 mg/L.
- Executive summary:
The water solubility of Ceramide III was determined via shaking method followed by visual check according to CIPAC MT 157.1 (CIPAC Handbook Volume F, “Physico chemical Methods for Technical and Formulated Pesticides”, W. Dobrat and A. Martijn (1995)).
No dissolution was observed at any time point of the study.
The water solubility of Ceramide III was determined to be < 10 mg/L at 20 °C.
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018-01-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- For details please see attached justification.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR estimation, for details please see attached justification.
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Specific details on test material used for the study:
- Used for calculation:
Smiles code: CCCCCCCCCCCCCCCCCC(=O)NC(CO)C(C(O)CCCCCCCCCCCCCC)O
CAS: 34354-88-6
Melting Point (°C): 124.00 - Key result
- Water solubility:
- 0 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- other: QSAR estimation
- Conclusions:
- The water solubility was estimated (WSKOW v1.42) to be 1.548E-008.
- Executive summary:
The water solubility of Ceramide III was estimated with EPI WSKOW v1.42. The substance is within the applicability domain of the model. The water solubilty is 1.548E-008 mg/L at 25 °C.
Referenceopen allclose all
Test Temperature
Table 1: Temperature Data, recorded hourly
Test |
Temperature [°C] |
||
Min. |
Max. |
Mean |
|
Graduated |
17.80 |
21.76 |
19.71 |
Volumetric flask |
20.09 |
20.29 |
20.16 |
Volumetric flask |
19.05 |
23.91 |
20.92 |
Test with Graduated Cylinders
Table 2: Results of the Preliminary Test for Water (100 mg at max. 10 mL)
Test item (nominal 100 mg) |
Volume of added water |
Test item concentration |
Homogenous solution |
99.5 |
0.1 |
995 |
no |
0.5 |
199 |
no |
|
1 |
99.5 |
no |
|
2 |
49.75 |
no |
|
5 |
19.9 |
no |
|
10 |
9.95 |
no |
Table 3: Results of the Preliminary Test for Water (10 mg at max. 10 mL)
Test item (nominal 10 mg) |
Volume of added water |
Test item concentration |
Homogenous solution |
11.0 |
0.1 |
110 |
no |
0.5 |
22.0 |
no |
|
1 |
11.0 |
no |
|
2 |
5.50 |
no |
|
5 |
2.20 |
no |
|
8 |
1.375 |
no |
|
10 |
1.10 |
no |
Table 4: Results of the Preliminary Test for Water (10 mg at max. 100 mL)
Test item (nominal 10 mg) |
Volume of added water |
Test item concentration |
Homogenous solution |
10.3 |
1 |
10.3 |
no |
5 |
2.06 |
no |
|
10 |
1.03 |
no |
|
20 |
0.515 |
no |
|
50 |
0.206 |
no |
|
80 |
0.129 |
no |
|
100 |
0.103 |
no |
Test with Volumetric Flasks
Table 5: Results of the Preliminary Test with Volumetric Flasks, stirred overnight at 20 °C
Test item (nominal 10 mg) |
Volume of water |
Test item concentration |
Homogenous solution |
10.134 |
100 |
101.34 |
no |
10.058 |
250 |
40.232 |
no |
10.006 |
500 |
20.012 |
no |
10.052 |
1000 |
10.052 |
no1 |
1) Still no homogenous solution after additional stirring for 21 h at room temperature; not even a significant amount of the used test item was observed to be dissolved
Description of key information
In a reliable test, the water solubility of Ceramide III was determined according to CIPAC MT 157.1 by shaking with assigned amounts of water with visual observation of turbidity. The water solubility was measured to be below 10mg/l at 20 °C.
The water solubility of Ceramide III was estimated with EPI WSKOW v1.42. The substance is within the applicability domain of the model. The water solubilty is 1.548E-008 mg/L at 25 °C.
According to the outcome of QSAR estimation, the water solubility of the substance is too low to be measured with conventional analytical techniques. For the purpose of risk assessment and classification, the value from the QSAR estimation is sufficient.
Key value for chemical safety assessment
- Water solubility:
- 0 mg/L
- at the temperature of:
- 25 °C
Additional information
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