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EC number: 947-646-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17th August 2017 - 18th September 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction Mass of Mixed Xylenes and Sulphur Monochloride
- IUPAC Name:
- Reaction Mass of Mixed Xylenes and Sulphur Monochloride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch 46000058
- Purity test date:Not applicable; substance is a UVCB
OTHER SPECIFICS:
Due to the low water solubility of the test item, a modification to the standard method of preparation for aqueous media was performed. The organisms were exposed to a Water Accommodated Fraction (WAF), as accepted by many regulatory authorities in the EU (ECETOC 1996, OECD 2000 and Singer et al 2000). Aqueous media are prepared by mixing test item with water for a prolonged period, the solution is left to settle and the test item phase siphoned off. The test organisms are exposed to the aqueous phase or WAF, containing dissolved test item and leachates from the test item. Exposure is expressed in terms of the original concentration of test item in water at the start of the mixing period irrespective of the dissolved fraction.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of the test solutions were taken at 0, 24, 48 and 72 hours and the cell densities determined by direct count using a Coulter Multisizer II electronic particle counter.
Water samples were taken from the control and the 100 mg ai/L test group at 0 and 72 hours for quantitative analysis of the test concentration.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Water Accommodated Fraction prepared over 23 hours. The WAF removed from mid-depth.
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchneriella subcapitata
- Strain: CCAP 278/4
- Source: Culture Collection for Algae and Protozoa (CCAP),SAMS Research Srevices Ltd, Scottish Marine Institute, Oban, Argyll, Scotland.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 21 ±1°C
- pH:
- The pH of the control and test solutions were 7.6 and 7.7 respectively at the start of the test.
The pH of the control and test solutions increased to 7.9 and 7.8 respectively at 72 hours. - Nominal and measured concentrations:
- Nominal - 100 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 ml glass conical flasks
- Six flasks each containing 100 ml of test solution were prepared for both the treatment group and the control group.
- Mean cell density of control at 0 hours : 4.91 x 10 ^3cells/ml
- Mean cell density of control at 72 hours : 5.10 x 10^5cells/ml
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- biomass
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
: - Reported statistics and error estimates:
- Student t-Test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 72 hour EC50 of 'Reaction mass of mixed xylenes and sulphur monochloride' was greater than 100 mg/l.
- Executive summary:
A GLP study was performed in accordance with OECD guideline 201, in order to assess the effect of 'Reaction mass of mixed xylenes and sulphur monochloride' on the growth of the algae Pseudokirchneriella subcapitata.
Following a preliminary range finding study, Pseudokirchneriella subcapitata was exposed to the water accomodated fraction of the test substance at 100 mg ai/l for a period of 72 hours. Six replicates were performed at the test concentration and of the control solution. Samples of the algal populations were removed daily and cell concentrations determined for each control and treatment group. No effect on the algal growth was observed from the test solutions, therefore the EC50 was defined as greater than 100 mg ai/L.
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