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EC number: 203-517-1 | CAS number: 107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests
- Author:
- Wild D, King MT, Gocke E & Eckhardt K
- Year:
- 1 983
- Bibliographic source:
- Food Chem Toxicol. 1983 Dec;21(6):707-19
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- other: mammalian erythrocyte micronucleus test (migrated information)
Test material
- Reference substance name:
- 3,7-dimethyloctane-1,7-diol
- EC Number:
- 203-517-1
- EC Name:
- 3,7-dimethyloctane-1,7-diol
- Cas Number:
- 107-74-4
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 3,7-dimethyloctane-1,7-diol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 10 - 14 weeks
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: olive oil
- Duration of treatment / exposure:
- 30 h
- Frequency of treatment:
- 1x
- Post exposure period:
- 30 h
Doses / concentrationsopen allclose all
- Dose / conc.:
- 516 mg/kg bw (total dose)
- Dose / conc.:
- 860 mg/kg bw (total dose)
- Dose / conc.:
- 1 204 mg/kg bw (total dose)
- No. of animals per sex per dose:
- 4
Examinations
- Tissues and cell types examined:
- polychromatic erythrocytes of bone marrow
- Details of tissue and slide preparation:
- The smears were stained according to the method of Schmid (Schmid W. 1976; Chemical Mutagens; edited by A . Hollaender; Vol4; p31; Plenum Press, New York). Slides were scored as described by Wild (Wild D. 1980; Archs Toxicol.; 43; 249).
- Evaluation criteria:
- No. of polychromatic erthrocytes
- Statistics:
- Statistical significance was determined according to the methods of Kastenbaum & Bowman (Kastenbaum M. 1970; Mutation Res. 9; 527).
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- Mortality 3/7 animals at highest dose
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
DOSE: mean number of micronucleated polychromatic erythrocytes (PE) per 1000 PE
516 mg/kg bw: 2.2 (4/4 animals survived)
860 mg/kg bw: 2.2 (4/4 animals survived)
1204 mg/kg bw: 2.6 (3/7 animals survived)
vehicle control: 2.0 (4/4 animals survived)
mean of the vehicle controls for all substances tested: 1.85
Applicant's summary and conclusion
- Conclusions:
- The substance was negative in an viivo micronucleus study in mice as it did not produce genetic effects on mouse bone marrow cells.
- Executive summary:
The micronucleus test on mouse bone marrow was performed to determine the mutagenic effects of the test substance. The test substance was tested at dose levels of 0, 516, 860 and 1204 mg/Kg.
The test substance failed to produce genetic effects in the micronucleus test on mouse bone marrow cells and is negative for gene mutation in vivo.
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