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EC number: 296-117-1 | CAS number: 92257-28-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE report is based on biodegradation in water study.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : 2-Naphthalenamine, N-(2-ethylhexyl)-1-[[4-(phenylazo)phenyl]azo]-, ar' and ar''-Me derivs.
- IUPAC name : N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine
- Molecular formula : C30H33N3
- Molecular weight : 435.60 g/mol
- Substance type : Organic
- Physical state : Liquid - Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Concentration of sludge: 30ppm
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- not specified
- Parameter followed for biodegradation estimation:
- other: BOD and GC
- Parameter followed for biodegradation estimation:
- other: BOD and HPLC
- Details on study design:
- Standard type
- Reference substance:
- not specified
- Key result
- Parameter:
- other: BOD
- Value:
- 0.2
- Sampling time:
- 14 d
- Remarks on result:
- other: 1. Not readily biodegradable
- Key result
- Parameter:
- other: GC
- Value:
- 0.3
- Sampling time:
- 14 d
- Remarks on result:
- other: 1. Not readily biodegradable
- Key result
- Parameter:
- other: BOD and HPLC
- Value:
- 0
- Sampling time:
- 28 d
- Remarks on result:
- other: Not readily biodegradable
- Details on results:
- 1. 0.2 % degradation were observed by BOD and 0.3 % by GC
2. 0 % degradation were observed by BOD and HPLC parameter. - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 1. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
2. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water. - Executive summary:
Biodegradation study was performed of the structurally and functionally similar read across chemicals. The studies are as mentioned below:
Study 1.
Biodegradation study was conducted for evaluating the percentage biodegradability of read across test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
Study 2.
Similarly study was conducted on structurally and functionally similar read across chemical. Biodegradation study was conducted for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water.
Thus based on both studies for structurally and functionally similar read across chemicals it can be concluded that the test chemical N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen -2-amine (92257-28 -8) was not readily biodegradable in water.
Reference
Description of key information
Biodegradation study was performed of the structurally and functionally similar read across chemicals. The studies are as mentioned below:
Study 1.
Biodegradation study was conducted for evaluating the percentage biodegradability of read across test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
Study 2.
Similar study was conducted on structurally and functionally similar read across chemical. Biodegradation study was conducted for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water.
Thus based on both studies for structurally and functionally similar read across chemicals it can be concluded that the test chemical N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen -2-amine (92257-28 -8) was not readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Various experimental data for the target compound N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and supporting weight of evidence studies for its
structurally and functionally similar closest read across substance were reviewed for the biodegradation end point which are summarized as below:
Study 1.
Biodegradation study was conducted for evaluating the percentage biodegradability of read across test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
Study 2.
Similarly study was conducted on structurally and functionally similar read across chemical. Biodegradation study was conducted for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water.
On the basis of above results for target chemical N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and for its read across substance from authoritative database, it can be concluded that the test substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl] naphthalen-2-amine (CAS No. 92257-28-8) can be expected to be not readily biodegradable in nature.
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