Registration Dossier
Registration Dossier
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EC number: 255-785-4 | CAS number: 42373-04-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973-01-23 to 1973-09-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- EC Number:
- 255-785-4
- EC Name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- Cas Number:
- 42373-04-6
- Molecular formula:
- C19H17N4S.Cl
- IUPAC Name:
- 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]thiazolium chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: clinical signs daily, weighing weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- n.a.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no data
- Clinical signs:
- no effects
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the results, the acute dermal LD50 in rats is greater than 5000 µL/kg body weight.
- Executive summary:
In an acute dermal toxicity study, rats were dermally exposed to the undiluted test item and were observed afterwards for 7 days. No clinical signs and no gross pathological effects were observed. Based on the results from this study, the dermal LD50 in rats can be considered to be greater than 5000 µL/kg bw. Due to poor documentation of the method and results, the study cannot be used for classification according to CLP criteria and is used as supporting information only.
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