O-isobutyl ethylthiocarbamate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

other: published data

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

O-isopropyl ethylthiocarbamate (IPETC) is the similar substance as O-isobutyl ethylthiocarbamate (IBETC). Therefore, the health effects of O-isopropyl ethylthiocarbamate (IPETC) need to be considered in the assessment of O-isobutyl ethylthiocarbamate (IBETC).

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

SPECIES
SPECIES #
(NAME): 4 Oncorhynchus mykiss (Rainbow Trout)
AGE: NR NR
LIFE STAGE: fingerling
COMMENT: 1-10 G

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

348 mg/L CaCO3
ALKALINITY: 203 mg/L CaCO3

Test temperature:

12 0C

pH:

8.6

Dissolved oxygen:

Saturated mg/l

Salinity:

SALINITY:NR

Nominal and measured concentrations:

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR

Details on test conditions:

TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 12 NR TO NR C
pH: 8.6 NR TO NR
HARDNESS: 348 NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: 203 NR TO NR mg/L CaCO3
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 40 - < 45 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 45 - < 48 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 9 mg/l (NOEC). One of the 96h-LC50 was between 45 and 48 mg/l

Details on results:

EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE:NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality

ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
GENERAL COMMENTS: LOC/NR// HARD,ALK,PH/OF DILUTION H2O// AERATED//

Validity criteria fulfilled:

yes

Conclusions:

Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l
O-isopropyl ethylthiocarbamate (IPETC) is the similar substance as O-isobutyl ethylthiocarbamate (IBETC). Therefore, the health effects of O-isopropyl ethylthiocarbamate (IPETC) need to be considered in the assessment of O-isobutyl ethylthiocarbamate (IBETC).

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: .US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

EPI Suite v 4.1/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fishes species

Details on test organisms:

no further information

Test type:

other: QSAR model

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

SMILES : O(C(=NCC)S)CC(C)C
CHEM : Carbamothioic acid, ethyl-, o-(2-methylpropyl) ester
CAS Num: 55860-53-2
MOL FOR: C7 H15 N1 O1 S1
MOL WT : 161.26
Log Kow: 3.81 (KowWin estimate)
Wat Sol: 37.72 mg/L (WskowWin estimate)

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

3.181 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

not specified

Details on results:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 3.181 mg/l was established.
Fish, 96-hr LC50 =3.181 mg/L (ppm)

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 3.181 mg/l was established.
Fish, 96-hr LC50 =3.181mg/L (ppm)
Fish, 96-hr (SW) LC50 =3.855mg/L (ppm)
Fish 30-day ChV =0.374 mg/L (ppm)
Fish (SW) 30-day ChV =1.311mg/L (ppm)
 Fish, 14-dayLC50 = 3.312 mg/L (ppm)
 

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 3.181 mg/l therefore the substance is moderately toxic to fishes.

Reference 3

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: .US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

EPI Suite v 4.1/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fishes species

Details on test organisms:

no further information

Test type:

other: QSAR model

Water media type:

saltwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

SMILES : O(C(=NCC)S)CC(C)C
CHEM : Carbamothioic acid, ethyl-, o-(2-methylpropyl) ester
CAS Num: 55860-53-2
MOL FOR: C7 H15 N1 O1 S1
MOL WT : 161.26
Log Kow: 3.81 (KowWin estimate)
Wat Sol: 37.72 mg/L (WskowWin estimate)

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

3.855 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

not specified

Details on results:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 3.855 mg/l was established.
Fish, 96-hr LC50 =3.855 mg/L (ppm)

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 3.855 mg/l was established.
Fish, 96-hr LC50 =3.181mg/L (ppm)
Fish, 96-hr (SW) LC50 =3.855mg/L (ppm)
Fish 30-day ChV =0.374 mg/L (ppm)
Fish (SW) 30-day ChV =1.311mg/L (ppm)
 Fish, 14-dayLC50 = 3.312 mg/L (ppm)
 

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 3.855 mg/l therefore the substance is moderately toxic to fishes.

Description of key information

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 3.181 mg/l therefore the substance is moderately toxic to fishes.

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 3.855 mg/l therefore the substance is moderately toxic to fishes.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

3.181 mg/L

Marine water fish

Marine water fish

Effect concentration:

3.855 mg/L

Additional information

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 3.181 mg/l therefore the substance is moderately toxic to fishes.

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 3.855 mg/l therefore the substance is moderately toxic to fishes.