Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-420-7 | CAS number: 53185-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 06 October 2011 to 08 October 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Details on study design: HPLC method:
- HPLC CONDITIONS
- HPLC system with autosampler, column oven and UV detector
- Column: LiChrospher 100 CN 250 x 4 mm, 5 µm
- Column temperature: 25°C
- Mobile phase: 30/70 (v/v) methanol/water
- Flow: 1 mL/min
- Injection volume: 20 μL
- UV detection: 210 and 254 nm
UNRETAINED SUBSTANCE, REFERENCE SUBSTANCES AND TEST SUBSTANCE SOLUTIONS
- Unretained substance: sodium nitrate
- 6 Reference substances with known log Koc values ranging from 1.25 to 3.31: Acetanilide, Methyl benzoate, Isoproturon, Linuron, Naphthalene and Fenthion
- Solution of the unretained substance in mobile phase (ca. 100 mg/L).
- Solutions of the reference substances in mobile phase (ca. 10 mg/L).
- Test item solution in mobile phase (ca. 10 mg/L).
INJECTIONS
-Three series of the above reference solutions and the test item solution were measured alternately, with two replicate injections.
-For the determination of t0 (retention time of the unretarded component) sodium nitrate solution was injected.
-The retention times were determined.
DATA HANDLING
- Dead time t0 =1.45 min (mean)
- Capacity factors (k') for each reference substance were calculated from the retention times (tr). k'= (tr-t0)/t0
- Log k’ values (mean) of the references substances were plotted against the known log Koc values.
- Linear regression analysis (least squares method) resulted in the regression line log k’ = 0.4059 log Koc– 0.3524 (r^2=0.986, n=6) - Key result
- Type:
- log Koc
- Value:
- < 1.25 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: non-buffered mobile phase
- Conclusions:
- The log Koc of the substance at ca. 20°C is < 1.25.
- Executive summary:
The HPLC estimation method was used for the determination of the adsorption coefficient (Koc) of the substance. The study was performed in accordance with EC C.19 and OECD 121 and in compliance with GLP. The mobile phase was 30/70 (v/v) methanol/water and the wavelength of detection 210 nm or 254 nm. The stationary phase contained cyanopropyl chains chemically bonded to silica. The substance eluted before the reference substance with known log Koc of 1.25: log Koc of the substance at ca. 20°C is < 1.25.
Reference
Description of key information
log Koc at 20°C is < 1.25 (EC C.19, OECD 121: HPLC estimation method).
Key value for chemical safety assessment
- Koc at 20 °C:
- 17.8
Additional information
HPLC-UV system with 30/70 (v/v) methanol/water as mobile phase and the wavelength of detection 210 nm or 254 nm. The stationary phase contained cyanopropyl chains chemically bonded to silica. The substance eluted before the reference substance with known log Koc of 1.25.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)