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Diss Factsheets
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EC number: 235-406-9 | CAS number: 12220-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- The 24-hour dermal toxicity was assessed using the technique of Noakes and Sanderson (1969).
Ref: Noakes DN. and Sanderson D.M. (1969) Br J Ind Med 26 59. - GLP compliance:
- no
- Remarks:
- pre GLP
- Limit test:
- yes
Test material
- Reference substance name:
- Acid Orange 067
- IUPAC Name:
- Acid Orange 067
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Alderley Park SPF.
- Weight at study initiation: 190 - 220 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST MATERIAL
Test item was applied as an aqueous paste.
REMOVAL OF TEST SUBSTANCE
After 24 hours the skin was washed with soap and water. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- Three rats
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Clinical signs:
- other: The skins were stained orange by the material, but no toxic signs were noted during the experimental period.
- Gross pathology:
- At autopsy there were no gross or microscopic findings indicative of pathology.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation (EC) No 1272/2008
- Conclusions:
- LD50 > 2500 mg/kg (females)
- Executive summary:
The 24-hour dermal toxicity was assessed using the technique of Noakes and Sanderson (1969). A group of three female rats (Alderley Park SPF albino strain) had 2500 mg/kg of the material, as an aqueous paste, applied for 24 hours under an occlusive dressing; the skin was then washed with soap and water and the animals observed for seven days.
The skins were stained orange by the material, but no toxic signs were noted during the experimental period. The 24-hour dermal LD50 is therefore greater than 2500 mg/kg. At autopsy there were no gross or microscopic findings indicative of pathology.
Conclusion
LD50 > 2500 mg/kg (females)
Ref: Noakes DN. and Sanderson D.M. (1969) Br J Ind Med 26 59.
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